RB Leipzig signalled their intent in the title race with a late come-from-behind victory over Borussia Mönchengladbach, while Bayern Munich, Borussia Dortmund and Wolfsburg all won again.
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Robert Lewandowski scored twice for the league leaders in a comfortable win at home to lowly Cologne.
Jadon Sancho hit his sixth goal of the season, while there were firsts of the campaign from Mahmoud Dahoud and Reinier as Dortmund breezed past Bielefeld.
Alexander Sorloth scored an injury-time winner as Leipzig fought from 2-0 down to beat Gladbach and keep the pressure on leaders Bayern.
Die Werkself dominated for much of the match but were undone by second-half goals from a clinical Freiburg side.
USMNT forward Josh Sargent scored the winner to end Frankfurt’s 11-game unbeaten run in the Matchday 23 opener.
The Wolves kept an eighth straight clean sheet to cement their place in third with victory over struggling Hertha.
Waturu Endo notched his first ever Bundesliga goals as Stuttgart cruised past crisis-hit Schalke at the Mercedes-Benz Arena.
Max Kruse continued his excellent penalty record, but it was only worth a point for Union Berlin at home to Hoffenheim.
Mainz goalkeeper Robin Zentner gifted Andre Hahn and Augsburg the only goal of the game in a win that leaves the 05ers deep in relegation danger.