Bayer 04 Leverkusen could welcome Mexican goal machine Javier 'Chicharito' Hernandez back when Hamburger SV visit the BayArena on Saturday (kick-off: 15:30CEST/13:30GMT).
With Bayer's 17-goal top scorer from last season recovering from surgery on his broken right hand, Die Werkself slipped to a 2-1 defeat at Borussia Monchengladbach on Matchday 1, conceding efforts that head coach Roger Schmidt later described as "annoying".
Hamburg went one better by picking up a draw 1-1 with FC Ingolstadt 04, thanks to an emphatic debut strike from USMNT international Bobby Wood, who HSV fans will be hoping can provide the catalyst for a positive result on the road on Matchday 2.
The Venue: BayArena
Leverkusen: Leno - Jedvaj, Tah, Toprak, Wendell - Kampl, Baumgartlinger - Brandt, Calhanoglu, Bellarabi - Hernandez
Absentees: Kießling (hip), Toprak (bruising), Volland (broken finger)
Head coach:Roger Schmidt
Hamburg: Adler - Sakai, Spahic, Djourou, Ostrzolek - Ekdal, Hunt - Müller, Gregoritsch, Kostic - Wood
Absentees: Ekdal (ankle), Jung (muscle tear)
Head coach: Bruno Labbadia