- Leverkusen looking for first win of 16/17.
- Wood marked Hamburg debut with goal.
- Hernandez may return from injury.
With Bayer's 17-goal top scorer from last season recovering from surgery on his broken right hand, Die Werkself slipped to a 2-1 defeat at Borussia Monchengladbach on Matchday 1, conceding efforts that head coach Roger Schmidt later described as "annoying".
Hamburg went one better by picking up a draw 1-1 with FC Ingolstadt 04, thanks to an emphatic debut strike from USMNT international Bobby Wood, who HSV fans will be hoping can provide the catalyst for a positive result on the road on Matchday 2.
- With an average age of 24 years and two months, Leverkusen took to the field with the youngest team in the Bundesliga on Matchday 1.
- Leverkusen have lost their opening two Bundesliga matches of the season on three occasions – the most recent being in 1994/95.
- Hamburg last avoided defeat in their first two games of the season in 2010/11.
- Four new faces were on target on Matchday 1, including Leverkusen's Joel Pohjanpalo and HSV's Wood.
- HSV have lost their last four games in Leverkusen.
- There has never been a goalless draw between the two clubs at Leverkusen's BayArena.
The Venue: BayArena
Leverkusen: Leno - Jedvaj, Tah, Toprak, Wendell - Kampl, Baumgartlinger - Brandt, Calhanoglu, Bellarabi - Hernandez
Absentees: Kießling (hip), Toprak (bruising), Volland (broken finger)
Head coach:Roger Schmidt
Hamburg: Adler - Sakai, Spahic, Djourou, Ostrzolek - Ekdal, Hunt - Müller, Gregoritsch, Kostic - Wood
Absentees: Ekdal (ankle), Jung (muscle tear)
Head coach: Bruno Labbadia