The north Londoners beat Peter Bosz's side 3-1 at Wembley back in September, with Kane scoring twice, but the forward, who sits second in this season's Champions League scoring charts with five goals (Real Madrid's Cristiano Ronaldo has six), is not being fooled by the ostensibly comfortable nature of that Matchday 1 win.
"Although we won 3-1 it was a really close game," Kane told Bild am Sonntag. "It's going to be a massive game in Dortmund in a breathtaking stadium with fantastic fans. Dortmund are obviously under pressure – they have to win both [of their remaining] games to have a chance of qualifying."
Watch: Sit back and enjoy all of Aubameyang's Bundesliga goals for Borussia Dortmund!
For their part, Spurs secured qualification for the knockout stages with a 3-1 win against back-to-back European champions Real Madrid at Wembley over a fortnight ago.
The roles are reversed from the last time the sides faced off at the Signal Iduna Park, when BVB prevailed by a 3-0 scoreline in the UEFA Europa League Round of 16 in March 2016, with Kane a late substitute.
Tottenham's development since that defeat, however, gives Kane plenty of reason for optimism coming into this meeting with Borussia.
"We're not fearful, we've found our style and we're winning our away games now," he said. "We're a bit more streetwise. My aim is to play for Tottenham my whole career. We have a fantastic team, a brilliant coach, a professional training ground and we're getting a new stadium. At the moment everything is working really nicely here for me and I'm happy."
Quiz: How well do you know Borussia Dortmund striker Aubameyang?