The Yellow-Blacks suffered a 5-1 aggregate defeat at the hands of Italian champions Juventus FC, and with 12 points currently standing between them and a place in the top four, it would appear that Europe's premier competition will have to do without Jürgen Klopp's dynamic bunch next season.
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13th-placed Hannover are in desperate need of a positive result after an alarming run of form that has seen Tayfun Korkut's side pick up just three points since the turn of the year. Dortmund are no longer thinking about relegation, but time's running out if they're serious about breaking into the top seven.
Club captain is expected to go straight into the starting XI following suspension. Borussia Dortmund loanee Leonardo Bittencourt is also an option in midfield after serving a mandatory one-match ban, but Andre Hofmann, Christian Pander and Artur Sobiech are all out.
With Marcel Schmelzer joining Lukasz Piszczek, Kevin Grosskreutz and Erik Durm on the sidelines, 19-year-old Jeremy Dudziak could be handed his Bundesliga debut at left-back. Influential holding midfielder Nuri Sahin is still unavailable due to a niggling abductor complaint.
was on target the last time these two sides met on Matchday 9, and also found a way past Manuel Neuer in the 3-1 home defeat to FC Bayern München on Matchday 23. Dortmund have experienced his dead-ball prowess firsthand and would do well not to concede too many unnecessary fouls in the final third.
Ten-goal leading scorer tends to be the man BVB turn to in their hour of need. The Gabon star was at his best in the derby win over FC Schalke 04, but hasn't found the net in three games since. Only once before in 2014/15 has he endured a lengthier barren run (five matches, November-December).
(Hannover midfielder): "It's a special game for me. I'll get to see the guys again, but at the end of the day I'm playing for Hannover to get three points. It doesn't matter who we're playing against, I always want to win."
Klopp (head coach): "We've got something to take care of in the Bundesliga on Saturday. We have to try and give it everything we've got. We haven't created as many chances as we did against Schalke since that game. We need to play like that more often. I'm going to make sure it happens."
Along with rock-bottom VfB Stuttgart, Hannover are the only team left in the Bundesliga without a win in 2015 (D3, L5). Dortmund are unbeaten in their last six league outings since losing to FC Augsburg on Matchday 19, but have been held to goalless draws in their last two.
A Kiyotake free kick gave the Reds their first win over BVB since September 2011 earlier in the campaign. Dortmund ran out 3-0 winners at the HDI Arena last term, though, and have scored at least once in all of their last nine outings on Hannover soil.
Hannover: Zieler - Joao Pereira, Marcelo, C. Schulz, Albornoz - Schmiedebach, S. Sané - Briand, Stindl, Kiyotake - Joselu
Dortmund: Weidenfeller - Sokratis, Subotic, Hummels, Kirch - S. Bender, Gündogan - H. Mkhitaryan, Kampl, Reus - Aubameyang