bundesliga.com brings you everything you need to know about the 146th Ruhr district classic...
A Revierderby is always about much more than just three points, although gaining those will be even more of a priority this time in view of the sides' respective league positions. Dortmund are steadily climbing away from relegation zone, while Schalke are firmly on the hunt for another top-four finish.
Jürgen Klopp could not avoid using an expletive when he was asked about his side's injury situation following Tuesday's 2-1 loss at Juventus. Lukasz Piszczek (r.) is out for six weeks, while Sokratis Papastathopoulos is a major doubt with a knock he took in Turin. Kevin Kampl could return from a viral infection, on the other hand.
Klaas-Jan Huntelaar has done his time and is now available again after suspension, giving coach Roberto Di Matteo a timely boost. "It's important to have him back," he said. "Klaas-Jan and Choupo have a great understanding on the pitch. His return's going to do us good." However, Joel Matip is out with an injury.
Marco Reus underlined once again how important he is to Dortmund with what could prove to be a crucial away goal against Juventus in the Champions League. Since putting pen to paper on a new contract, he seems to have shed a worry and is now delivering the goods again, in his inimitable, devastating style.
When faced with Dortmund's firepower, you need a sturdy hand at the back, and that is what Birthday boy Benedikt Höwedes should be able to supply. The German defender is one of the main reasons why Schalke's rearguard has become one of the most feared in the Bundesliga of late.
Pierre-Emerick Aubameyang (r.): "Once a fan came to me and said we can lose all our games, but not to Schalke. I think that says it all."
Höwedes: "The region is electrified by this duel – winning it would be a fantastic gift for all Schalke fans."
Dortmund's run of three straight Bundesliga defeats was punctuated by a 2-1 loss in the Champions League in midweek, although after a difficult first half of the season, things do appear to be going in the right direction for Klopp's men. Schalke also suffered recent Champions League disappointment, while they have eight points from five Bundesliga games in 2015.
Saturday's winner would go ahead in a head-to-head record which is finely balanced with 30 wins each and 25 draws in the Bundesliga. Schalke levelled things off with victory on Matchday 6. They have drawn and won on their last two visits to the Signal Iduna Park.
Dortmund: Weidenfeller - Sokratis, Subotic, Hummels, Schmelzer - Gündogan, Sahin - Blaszczykowski, Kagawa, Reus - Aubameyang
Schalke: Wellenreuther - Höwedes, Neustädter, Nastasic - Barnetta, Fuchs - Aogo - Höger, Boateng - Choupo-Moting, Huntelaar
Find out more background to the Revierderby in this video, courtesy of the Bundesliga's official YouTube channel.