Leverkusen - Bayer 04 Leverkusen must overturn a 1-0 first-leg deficit if they’re to strike down Serie A outfit SS Lazio and book their place in the group stages of this season’s UEFA Champions League on Wednesday night (kick-off: 20:45 CEST/ 18:45 GMT).

Die Werkself have home advantage on their side in the decisive second leg, but go into the contest knowing that anything other than a win will consign them to the UEFA Europa League instead of European football’s elite club competition.

Top facts

- Lazio substitute Balde Keita scored the only goal of the game in the 77th minute of last week’s first leg in Rome.

- Leverkusen are looking to reach the Champions League group stage for the tenth time in their history.

- Leverkusen have won four of their last five European home games, but Lazio have lost only one of their last 11 away fixtures in UEFA competition (W4, D6, L1).

- Leverkusen's home record against Italian clubs reads: W3, D1, L3.

- Lazio striker Miroslav Klose scored eight goals in 23 Bundesliga appearances against Leverkusen between 2000 and 2011 (W11, D5, L7), but misses Wednesday's trip to the BayArena with a thigh injury.

Team news

Possible line-ups:

Leverkusen: Leno - Hilbert, K. Papadopoulos, Tah, Wendell - Kramer, L. Bender - Bellarabi, Calhanoglu, Son - Kießling

Lazio: Berisha - Basta, de Vrij, Gentiletti, Radu - Cataldi, Parolo, Lulic - Candreva, Keita, Felipe Anderson