Bayer 04 Leverkusen have a tall order if they are to reach the last 16 of the UEFA Champions League, with the holders FC Barcelona paying the BayArena a visit on Wednesday night (kick-off 20:45CET/19:45GMT).

Die Werkself need to beat the European Champions and then hope that AS Roma slip up at home to BATE Borisov to clinch second in the group. A draw or defeat may carry the consolation of a place in the last 32 of the UEFA Europa League, but Leverkusen will be looking to take the lifeline they still have to progress in Europe's elite club competition on this date with destiny.

Click here for the permutations for the Bundesliga clubs in Europe this week.

Karim Bellerabi at the pre-match press conference: "We're looking forward to the game and want to give it everything we've got. We know it'll be difficult."

Top facts

  • Bayer need to beat Barcelona for the first time in seven attempts to stand any chance of progressing; their last six meetings have all ended in defeat.
  • Current Barcelona coach Luis Enrique netted home and away for the Catalans against Leverkusen in the 2001/02 group stage.
  • Enrique is up against FC Bayern München coach Pep Guardiola for the FIFA World Coach of the Year award.
  • Leverkusen are bidding to reach the last 16 for the third year in a row.
  • Die Werkself have failed to win any of their last five games in the Champions League, since beating BATE Borisov on Matchday 1.
  • Barcelona can end the group stage unbeaten for the first time in four years by avoiding defeat in Leverkusen.
  • Javier 'Chicharito' Hernandez is Leverkusen's form player with 11 goals in his last ten appearances in all competitions.
  • Barcelona are on a 12-game unbeaten streak in all competitions, while Leverkusen have lost three of their last five Bundesliga matches.

Click here to vote for Chicharito in the 'Bundesliga Idol' competition.

MD15 highlights: Hertha Berlin 2-1 Leverkusen

Roger Schmidt at the pre-match press conference: "Barcelona are about more than just Messi. They're strength is their team unity and individual quality."

Possible line-ups:

Leverkusen: Leno - Hilbert, Toprak, Tah, Wendell - Kampl, Kramer - Bellarabi, Mehmedi - Kießling, Hernandez

Barcelona: ter Stegen - Dani Alves, Mascherano, Bartra, Vermaelen - Sergi Samper, Busquets, Adriano - Suarez, Messi, Neymar