bundesliga.com previews the battle of two of the competition's firm favourites...
After eliminating another Italian side - FC Internazionale Milano - in the previous round, Wolfsburg have their sights set firmly on a trip to the Narodowy Stadium (l.) in the Polish capital on May 27. Napoli, like Wolfsburg, will be keen on getting a result that keeps their chances of qualifying for the next round alive.
Having reached such an advanced stage of the Europa League, VfL head coach Dieter Hecking won't be taking any chances against Napoli, fielding his strongest side to face the Italians with only long-term injury absentee Aaron Hunt (r.), who began individual training on Wednesday, out.
As a punitive measure after a string of poor results which saw Napoli drop to fifth in Serie A, and knocked out of the Coppa Italia, club president Aurelio De Laurentiis ordered the players into a training camp "until further notice". Rafael Benitez has a fully-fit side to choose from, including attacker Dries Mertens (l.).
The assist king in the Bundesliga is one of the big providers on the European stage too, with setting up five of Wolfsburg's 21 goals up to this stage in the Europa League. Furthermore, the Belgian wonderkid has netted five himself, making the 23-year-old the Wolves' top scorer in the competition.
Gonzalo Higuain (r.) has found the back of the net six times in Napoli's march through to the last eight, scoring a hat-trick in their 3-1 win over FC Dinamo Moskva in the last round which earned the Serie A side the right to meet the Wolves. The Argentina international is more than just a target man, and he needs only an inch to do damage.
De Bruyne: "We're playing a great season, but we can turn it into a fantastic one."
(r.) "I remember Napoli being a side who were very strong in the tackle and fought hard for every centimetre of grass [when going against them with Bayern]."
Rafael Benitez (coach, l.): "I and the team face every single game with the same intention - to win. We've known about Luiz Gustavo, Perisic and Schürrle for a long time now."
Lorenzo Insigne: "We have to give it our all now to win these two matches."
Wolfsburg are currently second in the Bundesliga with only one defeat in their last 17, and ten points from their last four games. Bas Dost (l.) and Co are also . Napoli were knocked out of their domestic cup by SS Lazio last week, but beat ACF Fiorentina 3-0 at the weekend to move to fourth in Serie A.
This is the first time these two sides meet in a competitive fixture. Wolfsburg's elimination of Inter in the last round was their second fixture against Italian opponents, the previous coming against AC Milan in the 2008/09 Champions League group stage. Napoli have have lost their last four matches on German soil.
Wolfsburg: Benaglio - Vieirinha, Klose, Knoche, Rodriguez - Guilavogui, Luiz Gustavo - Caligiuri, De Bruyne, Perisic - Dost
Napoli: Andujar - Maggio, Raul Albiol, Koulibaly, Ghoulam - Inler, David Lopez - José Callejon, Gabbiadini, Mertens - Higuain