There was little wrong in the way the Foals performed against the cup holders in Spain a week ago, but the 1-0 reverse at the Estadio Ramon Sanchez Pizjuan means they need to turn things around in front of a full house at Borussia Park. bundesliga.com previews the action...
Knocking out the reigning champions would be a huge confidence boost to Lucien Favre's side, who have failed to score more than once in a match since the turn of the year. Sevilla have Europa League pedigree, though, and having lifted the trophy three times in the past nine years, they will be hoping to keep their hopes alive of an extraordinary fourth final in that period.
With (r.) returning to action for the Foals at the weekend, Favre cannot complain about the number of players he has at his disposition. Gladbach have no suspensions either, although and are both a booking away from missing Borussia's next European encounter.
The Iberian club are having to contend with a much longer injury list than their hosts on Thursday evening. Iago Aspas, Coke and Stephane Mbia are all unavailable for coach Unai Emery, while no fewer than five players are just one warning away from suspension.
(pictured, l.) has become Borussia's man in Europe this season. After netting five in two qualifying games, he scored three times in the group stage and, since netting a dramatic late equaliser in Hamburg at the weekend, he will be brimming with confidence and keen to lead the Foals into the next round.
Sevilla's strength is not in their individuals but in their collective, according to Tino Polster, who represented both clubs during his playing career. Top scorer Carlos Bacca (l.) is often picked out for praise, but former Austria striker Polster told Marca: "He's just as important as his team-mates in attack. All of the players are important. There is not just one, let's say, who is world class. This is a good thing, though."
Max Eberl (Borussia sporting director): "This should be a night that we will never forget."
Vitolo (Sevilla midfielder): "We head there with an advantage, but the important thing is we get a goal no matter how. If we get one, they have to score three."
Last week's loss in Spain was only Gladbach's second of the new year, having won three of their five league encounters in 2015. Last weekend, they missed the opportunity to pull clear in third place in the Bundesliga table after being held by Hamburg. Meanwhile, with three defeats from their last four, Sevilla's hopes of qualifying for the UEFA Champions League next season are currently dangling by a thread.
Thursday's clash was the first between these two clubs, but Gladbach have lost only once at home to Spanish opponents (v RCD Espanyol in 1987) in their history, while Sevilla's record in Germany is an impressive four wins and a draw from seven visits. Only Hannover 96 (2011) and 1. FC Kaiserslautern (1982) have beaten them.
Gladbach: Sommer - Jantschke, Stranzl, Dominguez, Wendt - Xhaka, Kramer - Herrmann, Raffael, Hahn- Hrgota
Sevilla: Rico - Vidal, Pareja, Kolodziejczak, Navarro - Iborra, Krychowiak - Deulofeu, Banega, Reyes - Bacca