The former got their hands on the trophy that year, before coming mightily close to another in the final against German top-flight rivals FC Bayern München in May 2013.
bundesliga.com looks ahead to BVB's Juventus reunion...
An away goal can make all the difference in knockout football and, with Dortmund scoring 14 times on their way to topping Group D, the travelling fans have reason to be confident in Turin, even if Italian sides are traditionally seen as some of football's most stingy opponents.
Ex-Bayer 04 Leverkusen midfielder Arturo Vidal (r.) returned to training at the weekend following a groin problem and is expected to start at the Juventus Stadium, but the game comes too soon for Kwadwo Asamoah, Luca Marrone and Alessandro Matri.
Jakub Blaszczykowski and Henrikh Mkhitaryan are options on the right-hand side of midfield, should Kevin Kampl miss out after picking up a muscle complaint in the 3-2 win over VfB Stuttgart. Kevin Großkreutz remains sidelined, but German trio (r.), Sven Bender and Sebastian Kehl all return from the sidelines.
French midfielder Paul Pogba's (r.) reading of the game, athleticism and prowess in the final third continue to earn plaudits the world over. The 21-year-old has been a driving force for the Old Lady at home and abroad this season and will demand a lot of Dortmund's box-to-box specialist Ilkay Gündogan.
BVB's domestic upswing owes much to former AC Milan youth player , who has netted four goals in his last three outings. The Gabon international scored three times during the group stages and should get chances to add to his tally against a Juventus back four that's come under scrutiny of late.
Jürgen Klopp (Dortmund head coach, r.): "We're not going there as the favourites, but we'll try to get something from the game. We want a good result."
Massimiliano Allegri (Juventus head coach): "BVB in mid table [in the Bundesliga]? An anomaly. I think they'll be in and around the top spots come the end of the season."
Dortmund, who tasted defeat just once during the group stages, have won their last three in the Bundesliga. Serie A leaders Juventus haven't lost in the league since going down to Genoa CFC in October, but were beaten twice in Champions League Group A, qualifying for the last 16 in second place behind 2014 finalists Club Atletico de Madrid.
The two sides met 18 years ago in the final of the competition in Munich, where Dortmund ran out 3-1 winners thanks to a Karl-Heinz Riedle brace and a sumptuous Lars Ricken lob in the most memorable encounter yet. Two years earlier in the group stages, BVB picked up a 2-1 win in Turin, but lost 3-1 on home soil.
Juventus: Buffon - Lichtsteiner, Bonucci, Chiellini, Evra - Marchisio, Pirlo, Pogba - Vidal - Morata, Tevez
Dortmund: Weidenfeller - Piszczek, Sokratis, Hummels, Schmelzer - Sahin, Gündogan - Blaszczykowski, Kagawa, Reus - Aubameyang