bundesliga.com has all the essential pre-match build-up...
Simply put, a place in the knockout rounds is on the line for both sides. Neither can finish top of the group - Everton FC are guaranteed that honour - but the Wolves are in second place on seven points, three more than their hosts, so a draw would be enough to progress. Defeat for Wolfsburg would mean elimination from the competition due to the teams' head-to-head record.
The hosts are definitely without midfielders Florent Balmont (ankle) and Marvin Martin (groin), while Jonathan Delaplace (hamstring) and Marcos Lopes (thigh) are rated as doubtful.
Coach Dieter Hecking is spoilt for choice for the trip to northern France, with every member of his first-team squad available for selection. Striker (r.) is likely to get the nod up front after being substituted just 66 minutes into Saturday's win against Hannover in order to be rested for Thursday's tie.
Lille need to score if they want to reach the knockout stages - something they have only managed three times so far in Group H. That means forward Nolan Roux (r.), who netted one of those goals, is in for a big night. If Naldo and Co. can keep the Frenchman in check, the Wolves should be home and dry.
Having played in all five of Wolfsburg's group games so far, (l.) is the team's main threat going forward. The Belgium international has scored three goals and provided two assists in the Europa League this term, so any sights of goal will likely stem from him.
(r.), Wolfsburg midfielder: "My family and friends will be at the stadium. I hope we win and go through. I'm confident we can do it."
Franck Beria, Lille defender: "We've done well to earn a final chance in this group. Maybe there will be a happy ending. It's important to stay alive in this competition."
Lille have failed to win any of their 12 previous games in all competitions and have not won at all in the Europa League this season, drawing four and losing one. Wolfsburg are in fine form, having triumphed in eight of their last nine Bundesliga games, although they lost 2-0 at home to Everton in their last European fixture.
The only previous meeting between these sides was on Matchday 2 of the tournament back at the beginning of October. Lille went 1-0 up at the Volkswagen Arena from Divock Origi's penalty, but De Bruyne salvaged a 1-1 draw with a spectacular late strike.
Lille: Enyeama - Corchia, Basa, Rozehnal, Beria - Delaplace, Gueye, Mavuba - Mendes - Frey, Roux
Wolfsburg: Benaglio - Jung, Naldo, Knoche, Rodriguez - Gustavo, Guilavogui - Vieirina, De Bruyne, Perisic - Olic