bundesliga.com looks ahead to the Werkself's decisive clash in the Portuguese capital...
The hosts have nothing but pride to play for as they are guaranteed to finish bottom of the standings with FC Zenit three points ahead but boasting a superior head-to-head record. Leverkusen are already through to the Round of 16 and victory would secure them top spot and - theoretically - an easier draw in the knockout stages.
The hosts will be without Samaris and Luisao, who are both suspended for this game, but can recall Lisandro after he completed a two-match ban of his own. Defensive duo Eliseu (toe) and Silvio (leg) will miss out through their respective injuries.
(pictured) will be absent for the visitors as the midfielder is struggling with an abdominal injury and did not travel to Portugal with the rest of the squad. Kyriakos Papadopoulos (shoulder) and Stefan Reinartz (cheekbone) are also definitely out, while Giulio Donati (shoulder) is not expected to be fit in time.
Argentinian midfielder Nicolas Gaitan has played in all five of Benfica's group stage matches this term and is one of the side's main creative outlets. The No. 10 is a skilful attacker with the ability to play the killer pass, so the Bayer backline will need to be fully alert.
Roger Schmidt's side will need goals to settle any nerves - and also to give them the requisite win - so in-form attacker will have a crucial role to play. The 24-year-old is Leverkusen's top scorer with seven goals and two assists in the Bundesliga so far this season, and has also created two more in European competition.
(Leverkusen keeper, r.): It’s the Champions League and we’re playing a top team. They’ve got a great stadium and the atmosphere will be fantastic. It doesn’t get much better than that.
, Leverkusen midfielder: We want to stay top of the group going into the knockout stages.
Benfica, nicknamed The Eagles, have won their last six home games in all competitions, conceding just twice in that period. Leverkusen come into the game having lost 1-0 away to FC Bayern München on Saturday, but prior to that they impressed beating 1.FC Köln 5-1 and Hannover 96 3-1.
Benfica won both legs when they met Leverkusen in the Round of 32 in the UEFA Europa League in 2012/13, securing a 1-0 victory away and a 2-1 success at home. However, Hakan Calhanoglu's (r.) Bayer won 3-1 at the BayArena on Matchday 2 at the start of October in the current Champions League campaign.
Benfica: Artur Moraes - Maxi Pereira, Lisandro Lopez, Jardel, Andre Almeida - Cristante - Salvio, Gaitan - Perez - Talisca, Lima
Leverkusen: Leno - Jedvaj, Toprak, Spahic, Wendell - Castro, Rolfes - Bellarabi, Calhanoglu, Son - Kießling