bundesliga.com weighs up the permutations for Jürgen Klopp's Jekyll and Hyde ensemble, who have been enjoying a topsy-turvy few months so far in 2014/15...
With Dortmund and Arsenal FC having already qualified for the last 16, all that is left to decide is who tops the group. Victory against an Anderlecht side guaranteed a place in the UEFA Europa League will see Klopp's (l.) Borussia through as group winners, while a draw will also suffice as long as Arsenal fail to beat Galatasaray SK by six clear goals.
Mitchell Langerak (r.) and Roman Weidenfeller will battle it out for a starting berth between the goalposts. Turkish midfielder Nuri Sahin could win his first start of the season after a long spell on the sidelines, while Marco Reus, Sokratis Papastathopoulos and Sebastian Kehl are all out injured.
Klopp: "I trust Roman Weidenfeller 100% - but the same goes for Mitch."
Klopp: "Ich vertraue Roman Weidenfeller zu 100% - aber Mitch eben auch.“ #bvbrsca— Borussia Dortmund (@BVB) December 8, 2014
Bram Nuytinck and Matias Suarez will play no part owing to toe and knee complaints respectively. Midfield duo Steven Defour and Andy Najar are both nursing minor knocks, while Fabrice N'Sakala (l.), on the sidelines since suffering knee ligament damage in training on 3 September, could feature.
African Player of the Year nominee Pierre-Emerick Aubameyang's stellar performances have been one of few constants for the hit-and-miss BVB. Deployed on the right wing at the weekend, the Gabonese international added a seventh assist of the season to his ten goals in all competitions.
Youri Tielemans has been an ever-present for the Belgian champions in 2014/15 with 17 league and five Champions League appearances already under his belt this term. The 17-year-old holding midfielder never shirks a tackle and can be guaranteed to get in the Dortmund faces at the Signal Iduna Park.
(Dortmund centre-back, r.): We don't just want to win the group, we also want and have to prove that we've turned a corner.
Besnik Hasi (Anderlecht head coach): "The players that are fit and most deserving will play."
Klopp's side lost for the first time in this season's Champions League competition at Arsenal on Matchday 5, but moved off the foot of the Bundesliga standings with a 1-0 win over TSG 1899 Hoffenheim at the weekend. Anderlecht, meanwhile, were beaten 4-2 by Belgian Pro League newcomers Royal Mouscron-Peruwelz.
33-time Belgian league winners Anderlecht have lost six of their seven Champions League group stage encounters against German opposition, including Matchday 2's to Dortmund, who have won seven out of their last eight home group games in the competition.
Borussia Dortmund: Langerak - Piszczek, Subotic, Hummels, Schmelzer - Kehl - Aubameyang, S. Bender, Gündogan, Mkhitaryan - Ramos
Anderlecht: Proto - Vanden Borre, Mbemba, Deschacht, Acheampong - Kljestan, Tielemans - Conte, Praet, Cyriac - Mitrovic