London/Cologne - Borussia Dortmund will be glad to be leaving Germany again when they travel to face Arsenal FC in the UEFA Champions League on Wednesday evening (kick-off 19:45 GMT/20:45 CET).

With 12 points in four group games, they have more points in the Champions League than they have collected in 12 Bundesliga matches, while their place in the last 16 of Europe's premier club competition has already been assured. This Wednesday, they can clinch top spot and tank up on some much-needed self-confidence ahead of the trip to Eintracht Frankfurt next Sunday. previews the the Anglo-German encounter at the Emirates Stadium...

Dortmund have two objectives in London: avoiding defeat would secure top spot and a seeding for the last-16, whereas a win would be a boost to the Bundesliga in UEFA's five-year rankings. Arsenal, on the other hand, still need a win to be sure of joining Dortmund in the knockout stages, and three points on Wednesday would give them a chance of topping Group D.

Olivier Giroud is ineligible for Arsenal, despite making a quicker-than-expected recovery from a broken tibia. Former SV Werder Bremen and FC Schalke 04 midfielder Mesut Özil (pictured) is also unavailable due to a knee injury while Laurent Koscielny is a doubt with a calf strain.

Marco Reus is the latest defection for Dortmund with his ankle injury from the weekend leaving him out of action until January. He will be kept company back in Dortmund by Mats Hummels, Sokratis Papastathopoulos and Jakub Blaszczykowski.

Aaron Ramsey (pictured, r.) was the man Arsenal's hopes were pinned on in their eliminations to FC Bayern München in each of the past two seasons. The wily Welshman is again leading the Gunners' expectations at home and in Europe. "I still believe in my qualities and I'm confident I can show them again," said the 23-year-old.

With Reus sidelined, will have a greater role to play in the Dortmund side. The Armenian has a similarly lethal touch to Reus and, although he may not have provided as many goals and assists this season, he is the man who invariably gets Dortmund's attacks going.

Aaron Ramsey (Arsenal midfielder): "We've got to play the way we believe we should. We're looking forward to the game against Dortmund."

Michael Zorc (Dortmund's sporting director, pictured): "We want to go through to the last 16 as group winners."

Dortmund stopped the rot in the Bundesliga with victory over Borussia Mönchengladbach prior to the international break, but they had a relapse on Matchday 12, drawing 2-2 in Paderborn. Arsenal were beaten at home by Manchester United FC at the weekend and are 15 points adrift of Premier League leaders Chelsea FC.

It is the third time in four seasons that these two sides meet in the group stage, which means they already very well acquainted. The head-to-head record in these three years is even: Arsenal have won twice with Dortmund winning on their last two trips to London, and the other game ending all square.

Possible line-ups:

Arsenal: Szczesny - Chambers, Mertesacker, Monreal, Gibbs - Ramsey, Arteta, Santi Cazorla - Walcott, Welbeck, Sanchez

Dortmund: Weidenfeller - Piszczek, Subotic, Ginter, Durm - Bender, Kehl - Aubameyang, Kagawa, Mkhitaryan - Immobile