Bayern have the chance to get through the group stage with a perfect record, while the not-so-small matter of boosting the Bundesliga's position in the UEFA rankings should also give them plenty of motivation.
bundesliga.com previews the latest step on Bayern's road to European domination...
It goes without saying that the stakes are a lot higher for City, who risk being eliminated in the group stage if they fail to beat Bayern. The Premier League champions have to win to stand any chance of joining them in the round of 16, while the Bundesliga's record titleholders will be keen to preserve their perfect record in the competition.
Former VfL Wolfsburg forward Edin Dzeko is a doubt after picking up a calf injury at the weekend, but Frank Lampard (pictured, r.), who was among the penalty scorers for Chelsea FC in their victory over Bayern, is an option. David Silva is still sidelined, but former Bayern defender Martin Demichelis should be fit to face his ex-club.
is on Bayern's lengthy injury list, but (pictured), after making his first appearance of the season at the weekend, could well be given the chance to get some minutes under his belt. There could also be rare starts for the likes of Sebastian Rode and Xherdan Shaqiri with , who is carrying a knock, likely to sit this one out.
The Bundesliga already knows all about Edin Dzeko (pictured) with his 26 goals in the 2008/09 season contributing to VfL Wolfsburg clinching their one and only Bundesliga title, leaving him second in the league's top-scorer charts behind team-mate Grafite. After a difficult start, he has now emerged as a key member of the City attack, scoring almost a goal every two games.
Beating the Bayern defence is one thing, getting past Manuel Neuer is another. Having gone 329 minutes without conceding, it's hardly surprising the Germany number one is set to retain his FIFA FIFPro Goalkeeper of the Year award while the odds are shortening on the man with an invincible aura becoming the first custodian to lift the Ballon d'Or.
Manuel Pellegrini (Man City coach): "My team will be fighting to try and continue in the Champions League and I hope we will do it."
Karl-Heinz Rummenigge (Bayern CEO, pictured): "There are many reasons why we've got to take the game seriously and, hopefully, be successful. A win would be good for the Bundesliga."
Bayern are undefeated in 18 matches, since to Borussia Dortmund back in August. Defending Premier League champions City, on the other hand, have been inconsistent so far with Saturday's 2-1 win at Swansea City AFC only ensuring their eight-point deficit on league leaders Chelsea did not grow. They have yet to win in Europe this season.
Bayern have happy memories of their last visit to the Etihad Stadium with a 3-1 victory there little over a year ago thanks to goals from Franck Ribery, Thomas Müller (pictured l.) and Arjen Robben. The two teams also met in 2011/12 with Bayern winning 2-0 at home, but losing by the same scoreline in Manchester.
Man City: Hart - Zabaleta, Kompany, Demichelis, Clichy - Fernando, Lampard - Jesus Navas, Nasri - Jovetic, Aguero
FC Bayern: Neuer - Benatia, Dante, Juan Bernat - Rafinha, Xabi Alonso, Rode - Robben, Müller, Ribery - Lewandowski