bundesliga.com looks at how the two sides are shaping up ahead of Matchday 4's clash at the Petrovsky Stadium...
Things are hotting up in Group C, with all four participants still in with a shout of making the last 16. Leverkusen are the current favourites with seven points from three games, but that could all change if they fail to win away to Zenit and second-placed AS Monaco get the better of bottom side SL Benfica.
Andre Villas-Boas has no concerns in the injuries department and may well plump for the same starting XI that lost 2-0 at the BayArena a fortnight ago. Spanish holding midfielder Javi Garcia is, however, one yellow card away from a suspension.
Greek defender Kyriakos Papadopoulos (pictured) will not play again this year after suffering a shoulder injury in training. Simon Rolfes, Gonzalo Castro and Stefan Reinartz have also been ruled out, while Wendell is suspended following his sending off against the Russians two weeks ago.
Brazilian international striker Hulk has developed a fearsome reputation down the years, largely down to his burly physique and rocket-propelled shooting ability. The 28-year-old was kept quiet in Leverkusen, but made up for his subdued display with a goal against FC Mordovia Saransk four days later.
is set to make his 14th Champions League appearance on Tuesday. The South Korean has scored three times at Europe's top table since taking his bow in last season's competition against Manchester United FC and will be looking to add to his tally in Russia.
Hulk, Zenit striker: "Last time we were not lucky. At home it's going to be easier with our fans."
Roger Schmidt, Leverkusen head coach: "I'm expecting a physical match played at a very high level. We'll have to see how they set up, they didn't line up as we expected in Leverkusen."
Leverkusen went down 1-0 at Hamburger SV on Saturday afternoon, but have won their last two in Europe since losing at AS Monaco on Matchday 1. Zenit, meanwhile, bounced back from defeat in Leverkusen with back-to-back league wins over Mordovia and PFC CSKA Moskva.
Leverkusen gained a measure of revenge for 2007/08's UEFA Cup quarter-final defeat to Zenit with an impressive 2-0 win in the reverse fixture two weeks ago. Die Werkself have, however, lost their only other two competitive outings on Russian soil.
Zenit: Lodygin - Anyukov, Garay, Lombaerts, Criscito - Witsel, Javi Garcia - Hulk, Shatov, Danny - Kerzhakov
Leverkusen: Leno - Donati, Toprak, Spahic, Jedvaj - L. Bender, Öztunali - Bellarabi, Calhanoglu, Son - Kießling