bundesliga.com looks ahead to BVB's first trip to the Belgian capital in almost 25 years...
The pressure's mounting for injury-hit Dortmund, who are without a win in since beating Arsenal FC in their opening Group D encounter two weeks ago. On a more worrying note, Jürgen Klopp's men have shipped 11 goals in six Bundesliga outings compared to Anderlecht's nine in nine in the Pro League.
Belgian international Anthony Vanden Borre (pictured), who is yet to feature this season after fracturing his fibula at the 2014 FIFA World Cup, remains a doubt, while fellow defender Fabrice N'Sakala is out with a knee complaint.
Marco Reus, Jakub Blaszczykowski, Nuri Sahin, Oliver Kirch and Henrikh Mkhitaryan (pictured) will play no part. Ilkay Gündogan only recently returned to first-team training following a long-standing back problem, while Sebastian Kehl will have a late check on a niggling foot injury.
Serbian forward Aleksandar Mitrovic has made a flying start to the new campaign, scoring five goals in nine top-flight outings. Despite getting himself in some great positions against Galatasaray AS on Matchday 1, the 20-year-old is still awaiting his first Champions League goal in an Anderlecht shirt.
continues to outshine the new faces at BVB after taking his 2014/15 tally to seven goals in all competitions last weekend. The Gabon international has always had the pace to trouble opposition defenders, but now appears to have found the finishing touch too.
Besnik Hasi (Anderlecht coach): "For Dortmund, it's easier to play against Anderlecht than against Schalke. I expect they will be better on Wednesday."
: (pictured) "It's been a tough eight days. The comeback trail starts at Anderlecht."
The 33-time Belgian champions, who held Galatasaray to a 1-1 draw on Matchday 1, have a four-point lead over second-placed KAA Gent following a nine-match unbeaten start to the domestic campaign. Despite outclassing the Gunners a fortnight ago, Dortmund find themselves way down the Bundesliga pecking order in 12th place.
The two sides have met twice before, with Anderlecht triumphing on the away-goals rule in the third round of the now defunct UEFA Cup back in 1990.
Anderlecht: Proto - Colin, Mbemba, Nuytinck, Deschacht - Najar, Defour, Tielemans, Conte - Suarez, Mitrovic
Weidenfeller - Piszczek, Subotic, Hummels, Schmelzer - Kehl, S. Bender - Aubameyang, Kagawa, Großkreutz - Ramos