After a strong performance away to Chelsea FC in their opening match, the Royal Blues will be looking for maximum points here. Maribor may have other ideas, however. Despite being widely-tipped to finish bottom of the group, they held Sporting Lisbon to a very creditable 1-1 draw last time out.
bundesliga.com takes a closer look at the clash...
With all four sides drawing on Matchday 1, Schalke have a decent chance to gain an early lead in Group G, with Chelsea facing a potentially tricky trip to Lisbon in the group's other encounter. If they are to progress to the knock-out stages, this is exactly the sort of game the Bundesliga side will probably have to win.
Julian Draxler, who missed the weekend's derby win over Borussia Dortmund through suspension, will return to the side in place of Sidney Sam, who is out with muscle problems. (pictured) will continue to deputise for injured captain Benedikt Höwedes in defence.
Maribor's 25-man squad flew into Germany on Monday morning and trained at the Veltins Arena in the evening. They have reported a largely clean bill of health, the only doubts being defender Petar Stojanovic (pictured) and Senagalese midfielder Welle N'Diaye, whose condition will be monitored ahead of late fitness tests.
2014 FIFA World Cup winner Draxler has perhaps not hit his best form so far this season. He did, however, show his class with a Matchday 4 goal against Eintracht Frankfurt before being dismissed in the same game, and will be looking to build on the positives of that performance here.
Brazilian striker Marcos Tavares was the man who fired Maribor into the Champions League group stages with a late winner away to Celtic. Tavares, who has been a Maribor mainstay since arriving at the club in 2008, also has three league goals to his name this season and will be hoping to add to his tally in Gelsenkirchen.
Jens Keller (Schalke head coach): "If we concentrate for the entire match and show our desire to win, then we have a good chance. We will go for it and hope to come away with a victory."
Mitja Viler (Maribor defender): "It's special to play in Germany, a great football country."
Keller's men recorded their first win of the season against SV Werder Bremen on Matchday 5, before downing Borussia Dortmund in the Revierderby four days later. After drawing 0-0 with Radomije, meanwhile, Maribor sit second in Slovenia's Prva Liga.
This will be the first ever meeting between the two sides. If the Slovenians' record against other German opposition is anything to go by, however, then Schalke will be feeling optimistic. They have failed to win any of their matches against the Royal Blues' compatriots and have scored only once: in a 2-1 UEFA Cup defeat to Borussia Dortmund in 1993/94.