bundesliga.com has everything you need to know ahead of the big game...
Bayer's Group C looks to be an open affair. Away from the game in Monaco, Benfica are hosting Zenit St. Petersburg with none of the four teams looking like clear favourites. If the Bundesliga side can set down a marker in their opening game, they will give themselves a strong platform for qualification.
Following Saturday's 3-3 thriller at home to Werder Bremen, Bayer should be largely unchanged heading into their first European game of the season. (pictured) is a possible replacement for Levin Öztunali having come on for him at the weekend; Simon Rolfes remains sidelined with an ankle problem, while Kyriakos Papadopoulos and Julian Brandt also miss out.
Despite their 2-1 defeat to Lyon at the weekend, Monaco are not expected to make many changes. Fabinho could return to the side in place of Dirar, while former Leverkusen boy Dimitar Berbatov (pictured) should lead the line against his old club. Abdennour is the only notable absentee, ruled out with a thigh injury.
joined Bayer this summer from Bundesliga rivals Hamburg. Having found the net 11 times last season with HSV, the attacking midfielder notched Bayer's second goal in their 3-3 draw with Werder at the weekend and will be chomping at the bit to build on this at Monaco.
Argentinian midfielder Lucas Ocampos opened his account for the season with a well-taken goal at Lyon on Friday night. The quick wide-man, who joined Monaco two years ago, will be looking to add to his tally on Tuesday when he makes his Champions League bow.
Roger Schmidt (Leverkusen, pictured): We have had big tests already in the league and in the play-offs, so we have been able to apply our new style. We have succeeded, so this is not our first big test.
Leonardo Jardim (Monaco): Leverkusen are strong and very quick on the break. We will have to raise our game and be efficient up front.
Bayer Leverkusen's 3-2 away victory at FC Copenhagen in the Champions League play-off qualifier was followed up with a comfortable 4-0 home win to secure their passage to the group stage. Until Friday night's draw against Werder Bremen, Bayer boasted a 100 per cent record in the league.
The two sides have only met twice before, in the 1997/98 Champions League group stage. A Thierry Henry-inspired Monaco side recorded a comfortable 4-0 victory at home, with the French striker and his team-mate Victor Ikpeba both bagging braces. In the return match Leverkusen took a 2-0 lead, only to be pegged back for a 2-2 draw.