A win by a minimum of two goals against the Italian outfit would keep Jürgen Klopp's charges just about on track ahead of their visit to Olympique de Marseille on 11 December, with Arsenal FC currently leading Group F.
'Have to win next two games'
"We want make sure we go into the final game with everything to play for," said Klopp at his pre-match press conference on the night before Tuesday’s pivotal tie at the Signal Iduna Park. "No one is safe in this group. It's widely been regarded as the toughest in the competition, and we'll have to make sure we win the next two games."
However, after losing their previous three outings - one in the Champions League and two in the Bundesliga, where Dortmund suffered a 3-0 home defeat to FC Bayern München in der Klassiker, Klopp admitted he had a bit of work to do to help rebuild his players’ confidence before focusing on the Napoli job.
'Under a bit of pressure'
"I told the team after the Bayern game they have five minutes to be depressed and come to terms with the defeat," Klopp said. "We now have to deal with the next tough task. Trust me, we'll come back strong. The defeats can't throw our players off the track," the former 1. FSV Mainz 05 boss insisted, nevertheless admitting: "We're certainly under a bit of pressure. Beating Napoli won't at all be easy."
With newly-signed centre-back Manuel Friedrich ineligible for the Champions League, Klopp will again be forced to shuffle his pack following injuries to defenders Mats Hummels, Neven Subotic and Marcel Schmelzer. The charismatic 46-year-old is, therefore, likely to field either Sebastian Kehl or Sven Bender, holding midfielders by trade, alongside Sokratis at the heart of defence, while BVB received a welcome boost after Lukasz Piszczek made his return from a lengthy spell on the sidelines as a substitute at the weekend.
Despite his side's injury woes, Sokratis, for one, believes Dortmund have what it takes to contend with their numerous absentees. "Our squad is very strong, giving us several options," the Greece international defender pointed out. "We'll have to work hard and give our all. This game is a basically a final for us, this is not the time for excuses.”
Having missed several good opportunities in the previous Matchday 1 meeting in Naples, where ten-man Dortmund fell to a 2-1 defeat, goalkeeper Roman Weidenfeller insisted die Schwarzgelben would have to do better this time in one department in particular. "We must take our chances. It's taken us too long to finish in recent games." Much will therefore depend on Robert Lewandowski, the current leading goalscorer in the Bundesliga on nine goals.
Dortmund: Weidenfeller - Großkreutz, Sokratis, Kehl, Durm - S. Bender, Sahin - Blaszczykowski, Mkhitaryan, Reus - Lewandowski
Napoli: Reina - Maggio, Raul Albiol, Britos, Armero - Behrami, Inler - Jose Callejon, Pandev, Mertens - Higuain