The 22-year-old midfielder is still struggling with a left groin problem sustained in Friday's 2-0 win over Hamburg.
"Unless there's a miracle, Naby Keita won't feature tomorrow," Hasenhüttl said at Tuesday's pre-match press conference. "Losing Naby hurts, but we have players that can fill the void."
Liverpool-bound Keita registered eight goals and as many assists in 31 Bundesliga appearances in 2016/17, and has started all three of Leipzig's top-flight outings so far this term, opening his account for the campaign against Hamburg.
Watch: Naby Keita's top 5 Bundesliga goals
Leipzig record signing Kevin Kampl - a second-half substitute last time out - is expected to make his full debut in Keita's stead.