The talismanic duo have been in electric form so far in 2018/19, spearheading their respective side's push for UEFA Champions League football - and possibly more.
With four points standing between fourth-placed Leipzig and second-in-the-table Gladbach at the time of writing, who will win out at the Red-Bull Arena? And what role will the supporting cast have to play? bundesliga.com weighs up the key battles...
There's a battle in Borussia ⚔️ pic.twitter.com/5LkeLwuLLU— Bundesliga English (@Bundesliga_EN) November 25, 2018
Werner vs. Hazard: The flying machines
There's no better place to start than the all-action heroes doing the business in front of goal.
A turbo-charged forward with licence to roam, Leipzig's Werner already has six goals in 12 outings. He's also chimed in with an assist, while all his goal-scoring efforts have come in twos - in wins against Hannover, Nuremberg and Hertha Berlin. But then he has fired off more shots on goal than any other player in the Bundesliga this term (51).
Suffice to say the Germany international is comfortably on track to record a third successive double-digit haul after hitting 13 last season and 21 - a best for a German national - in 2016/17.
Not that Werner should be measured purely on his end product. His pace makes him a real asset, above all on the counter where Leipzig have proved so effective since gaining promotion to the Bundesliga for the first time in 2016.
Goal threat and foot speed: it's a potent combination Hazard has mastered with equal finesse.
Is he a winger? Could he be a No.10? Perhaps he's a thoroughbred forward? The truth is, he's a bit of all three. A taker and maker, with a trigger-happy return of eight goals and five assists in his last nine outings. And just to reiterate - no, we're not talking about Eden, of Chelsea fame.
Young Thorgan is ploughing his own Hazard-ous furrow for Gladbach. So much so that he already has more goals and assists than his bigger bro after 12 league matches.
A missed penalty against Bayer Leverkusen is the only blot to his copybook - although he remains the current Bundesliga campaign's highest scorer from 12 yards (four). The bothersome Belgian is also fourth on the list of most-fouled players this term. Leipzig, watch your step.
Watch: Find out what makes Thorgan Hazard such a threat
Poulsen vs. Plea: The goal-scoring centre-forwards
Of course, every p-p-p-p-player worth his salt needs a reliable wing man, and Messrs Werner and Hazard are no exception.
Leipzig battering ram Yussuf Poulsen is the perfect foil for his turbo-charged strike partner, the 6'3" front man's rough-and-ready approach putting him at 52 per cent in the aerial-challenges-won department. He's making the most of his chances, too, with six goals in 12 matches a personal best for the Dane in a single season.
That's as many as Werner, and only two fewer than Gladbach's leading men, Hazard and Alassane Plea.
Plea doesn't pose quite the same physical threat as Poulsen, but the 5'9" forward packs just as much punch - if not more.
Two better off in the scoring charts than his Leipzig counterpart, the summer signing from Nice even heads Hazard for goals per game with eight in 11.
That bountiful debut-season return includes a stunning hat-trick at Werder Bremen, making him this term's most prolific marksman on the road, with seven of his eight strikes coming away from Borussia-Park. He's even found the net at Bayern Munich's Allianz Arena. Who said size matters?
Watch: See how Alassane Plea compares to Timo Werner
Sabitzer vs. Hofmann: The providers
Plea's prolific induction owes much to the servicemen in midfield as it does to Hazard, albeit with one under-the-radar standout in particular.
Fit, healthy and playing the best football of his career, the 26-year-old has already posted a combined career-best return for a single campaign of five goals and three assists in 11 appearances.
Watch: Jonas Hofmann scored his first career hat-trick on Matchday 8
It's a role Leipzig haven't managed to fill quite so effectively in the on-going absence of Emil Forsberg.
The Sweden international supplied a league-leading 19 assists in 2016/17, but has provided only four since, with two coming this season.
He's missed Leipzig's last four matches with a nagging groin problem, leaving the onus on Marcel Sabitzer (two goals, two assists) to assume creator-in-chief duties for the visit of Gladbach.
Kampl vs. Neuhaus: The midfield dynamos
Kevin Kampl has also been doing a good job running the Leipzig supply line, with a team-leading three assists coming in successive wins over VfB Stuttgart, Hoffenheim and Nuremberg between Matchdays 5-7.
Happily averaging 7.5 miles per game, the Slovenia international's industry is second-to-none, while his big-game experience (104 Bundesliga appearances) far outweighs that of opposite number in the Gladbach engine room, Florian Neuhaus.
That's because Neuhaus was a virtual unknown last season, which he spent on loan in Bundesliga 2, working his socks off for promotion-winning Fortuna Düsseldorf.
Gladbach coach Dieter Hecking duly ordered him back to the black-and-green side of the Rhineland, and the 21-year-old has not disappointed.
Restricting senior internationals Christoph Kramer and Denis Zakaria to a bit-part role with his 84 per cent pass completion and joint-league-leading six assists - a tally he shares with Frankfurt striker Sebastien Haller and Dortmund winger Jadon Sancho - Neuhaus is the unsung conductor orchestrating what could yet be Gladbach's greatest symphony.
Gulacsi vs. Sommer: The shot-stoppers
As well as a free-scoring attack and energetic midfield, Gladbach's title push has been built on a steely last line of defence otherwise known as Yann Sommer.
The Switzerland international goalkeeper has conceded just 14 goals so far this season, keeping clean sheets in four of the Foals' 12 Bundesliga outings. He boasts a Manuel Neuer-esque command of his defensive charges, while his reach and reactions - he's thwarted 75.9 per cent of efforts on his goal - are enough to make doppelgänger Rafael Nadal wince.
Watch: Where does Yann Sommer ranks among the top 10 Bundesliga goalkeepers on FIFA 19?
Only two Bundesliga stoppers have recorded more shut-outs than Sommer, but only one has a superior ratio when it comes to shots saved. You guessed it, Leipzig's Peter Gulacsi.
Second to Dortmund's Roman Bürki for clean sheets, Gulacsi has been a busy beaver in 2018/19, but he has displayed the concentration and confidence levels to match.
In 1144 minutes of Bundesliga action, the former Liverpool custodian has faced 44 shots on his goal, repelling 33 of them. That's pushing 80 per cent - and it could be a game-changer for a Leipzig side that leaked the fourth-highest number of goals in the Bundesliga last season (53).
Needless to say, Hazard and Co. will need to be razor-sharp to cut through Gulacsi and the gang...