Bayer Leverkusen's Kai Havertz is one of three new faces called up by Joachim Löw for Germany's opening fixture of the inaugural UEFA Nations League against world champions France and their international friendly with Peru.
Jonas Hector of Bundesliga 2 club Cologne retains his place, alongside 11 Bundesliga-based World Cup finalists.
UEFA Nations League explained
The Nations League is a new international tournament, designed to take the place of friendly matches.
The 55 UEFA nations have been split into four leagues - A, B, C and D - based on their UEFA coefficient (ranking). Within those leagues, teams have been drawn into mini groups of three or four, and will play each other home and away during the September, October and November international breaks.
The four group winners of League A will qualify for the UEFA Nations League Finals, to be played in June 2019. The 'Final Four' competition will comprise two one-legged semi-finals, a third-place match and the final, where the winner will be crowned Nations League champion.
In Leagues B, C and D, group winners will gain promotion. The teams that finish bottom of their groups in Leagues A, B, C and D will be relegated.
Germany are in Group 1 of League A, along with France and the Netherlands.
UEFA EURO 2020 qualification
Qualifying for UEFA EURO 2020 remains largely the same, although the European Qualifiers - the draw for which takes place on 2 December - will now begin in the March following a major tournament instead of September. The teams will be split into ten groups of five or six, with the top two from each group qualifying directly for the finals, determining the first 20 places.
The last four places will will be determined via the play-offs, contested by the 16 UEFA Nations League group winners - or the next best placed team if the group winners have already qualified via the traditional route. The play-offs will take place in March 2020.