Cologne - The Rhine derby, a sell-out crowd in Darmstadt, Borussia Dortmund with a record to preserve, Julian Draxler in green and white and FC Ingolstadt 04 one win from history.
bundesliga.com picks out five of the most intriguing sub-plots to Matchday 5...
1) Gladbach still searching
Borussia Mönchengladbach have never started a season as badly as they have in 2015/16 - with four successive Bundesliga defeats - but that run is only going to continue unless they can come away from their trip to Rhine rivals 1. FC Köln with a positive result. The two sides meet at the RheinEnergieStadion on Saturday afternoon, with hosts Köln themselves smarting from last weekend's 6-2 defeat to Eintracht Frankfurt.
2) David vs Goliath
Fresh from their surprise 1-0 win away to Bayer 04 Leverkusen, SV Darmstadt 98 - unbeaten since gaining promotion to Germany's top tier - welcome champions FC Bayern München to the Merck-Stadion am Böllenfalltor. Tickets for that one flew off the shelves like hotcakes, which is hardly a surprise given that it is the Lilies' first meeting with Germany's most successful club since 23 January 1982. The final score in that one? Bayern 4-1 Darmstadt. In fact, the Hessen club have never beaten the men in red in six attempts.
3) 10 and counting
Borussia Dortmund's title credentials will be put to the test when they host Leverkusen on Sunday evening. BVB lead the way at the top of the standings after winning all four of their league assignments to date, and all ten competitive matches under Thomas Tuchel. It is a tough ask even for Bayer 04, who will look to veteran striker Stefan Kießling for inspiration on what is set to be the 31-year-old striker's 350th Bundesliga appearance.
4) Draxler to the fore
VfL Wolfsburg were left frustrated by a goalless draw at promoted FC Ingolstadt 04 on Matchday 4, but the Wolves bounced back in the best way possible on their first outing in the UEFA Champions League for six years in midweek. Julian Draxler scored the winner on his home debut against Russian outfit PFC CSKA Moskva, with Dieter Hecking's new-look title hopefuls proving there is indeed life after Kevin De Bruyne. Bad news, then, for Saturday's visitors Hertha Berlin.
5) History in the making
Following victories on the road against 1. FSV Mainz 05 and FC Augsburg, Ingolstadt can make history this weekend as the first newly promoted club to win their first three away matches of the season. To do so, however, die Schanzer will have to win their first ever competitive encounter with SV Werder Bremen.