Two of the most renowned tactical tinkerers in the league, expect Schmidt and Nagelsmann to make changes from the teams they sent into battle a fortnight ago when they meet this Sunday (kick-off 17:30CEST/15:30GMT).
Mainz possible line-up: Lössl - Donati, Bell, Balogun, Brosinski - Frei, Rodriguez - Clemens, Malli, de Blasis - Cordoba
Absentees: Berggreen (knee), Curci (calf), Samperio (knee), Zimling (cruciate ligament), Latza (adductor), Ramalho (muscular)
Head coach: Martin Schmidt
Hoffenheim possible line-up: Baumann - Toljan, Schär, Süle, Ochs - Schwegler, Rudy, Rupp - Uth, Kramaric, Wagner
Head coach: Julian Nagelsmann