BVB's 1-1 draw at Schalke in the Revierderby coupled with third-in-the-table Hoffenheim's win at Hertha Berlin means Dortmund start the week in fourth place, one point adrift of the automatic qualification places for the UEFA Champions League and five behind second-placed RB Leipzig.
Thomas Tuchel's side are unbeaten in their last six, however, and will be determined to keep spirits high ahead of Saturday's Der Klassiker with Bundesliga leaders Bayern Munich.
Hamburg suffered a chastening 5-2 home defeat to Dortmund earlier in the season, but have improved significantly since.
Indeed, the Red Shorts have taken ten points from the last 12 on offer, with their 2-1 win over Cologne on Matchday 26 lifting them a point and three places above the relegation play-off spot with eight fixtures remaining.
- Borussia are unbeaten in 33 home games. There have only been four longer runs in the history of the Bundesliga (two by Bayern and once each by Werder Bremen and Hamburg).
- Only one player has scored four goals in a game this season, and that was Pierre-Emerick Aubameyang in the 5-2 win over HSV earlier this season.
- Die Schwarzgelben and the Red Shorts meet for the 100th time in the Bundesliga (35 wins for BVB, 36 for HSV and 28 draws).
- Hamburg have 10 of a possible 12 points from their last four games, remaining unbeaten.
- No match-up in Bundesliga history has seen more goals than BVB vs. HSV (355 in 99 meetings).
- Only HSV (228) coomplete more sprints per game than BVB (223).