A run of four defeats in five Bundesliga games has brought an end to Valerien Ismael's short spell in charge of Wolfsburg.
The news comes on the back of a 2-1 home loss against Werder Bremen that leaves the Wolves just two points above the relegation zone.
"After weighing up all the facts, we agreed that a parting of ways is the right way to get the team back on the track," said Wolfsburg sporting director Olaf Rebbe.
"Our decision wasn't based purely on the most recent result against Werder Bremen, but also the results over the last weeks and months. At the end of the day, it's a results business and we have to find a way to improve."
Watch: Highlights of Wolfsburg's home defeat to Bremen:
Initially appointed on an interim basis on 17 October 2016 following the dismissal of current Borussia Mönchengladbach boss Dieter Hecking, and then in a full-time capacity from 6 November, Ismael oversaw just five wins in 15 Bundesliga matches.
The Wolves, 14th in the Bundesliga standings after 22 matches, travel to Mainz next Saturday.
Watch: Wolfsburg's Borja Mayoral calls for improvement after Bremen defeat: