Possible line-ups: Bayer 04 Leverkusen vs SV Darmstadt 98
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Captain Lars Bender is a doubt after suffering a bruised heel. Stefan Kießling is expected to return up front alongside Chicharito in place of Admir Mehmedi as one of several changes to the side that won 2-1 at Wolfsburg. The expected changes of Kießling for Mehmedi and Hakan Calhanoglu for Julian Baumgartlinger in midfield are the only ones from the side that beat Tottenham Hotspurs on Wednesday.
Watch: Highlights of Leverkusen's 2-1 win against VfL Wolfsburg:
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Norbert Meier is expected to make two changes to the side that lost 2-0 against RB Leipzig. Antonio-Mirko Colak is in line to replace Sven Schipplock up front and Fabian Holland is set to play at left-back in place of Leon Guwara. Sandro Sirigu is expected to be fit again for Saturday.
Watch: Highlights of Darmstadt's Matchday 9 defeat to RB Leipzig:
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Leverkusen possible line-up: Leno - Henrichs, Toprak, Tah, Wendell - Calhanoglu, Aranguiz - Brandt, Kampl - Kießling, Hernandez
Absentees: Bellarabi (tendon), Yurchenko (broken leg), Pohjanpalo (broken metatarsal), Volland (suspended)
Coach: Roger Schmidt
Darmstadt possible line-up: Esser - Höhn, Milosevic, Sulu, Holland - Gondorf, Jungwirth - Ben-Hatira, Kleinheisler, Bezjak - Colak
Absentees: Rosenthal (calf), Platte (hip)
Coach: Norbert Meier
Bayer 04 Leverkusen host SV Darmstadt 98 at the BayArena with the game kicking off at 15:30CET/14:30GMT on 5 November.