With just two points separating the teams going into the final matchday of the season, both need a victory to ensure survival. bundesliga.com has the latest pre-match team news and information...
This game is about escaping the claws of relegation, plain and simple. The hosts are bottom of the table on 31 points, while Stuttgart are in the play-off spot on on 33 points. The guests' fate is in their own hands, but Paderborn must win and hope that other results go their way in order to avoid the drop.
Set-piece specialist Alban Meha (r.) is still absent following elbow surgery, while Marvin Ducksch (broken foot), Thomas Bertels (fitness) and Daniel Brückner (suspended) are also sidelined.
With no fresh injuries or suspensions to factor into his plans, coach Huub Stevens has a full squad to choose from for the trip north.
Winger has impressed in his debut Bundesliga season, and although he only has one goal and two assists to his name thus far, he is a constant menace on the right wing. His direct running, drive and determination could be crucial to Paderborn's chances of securing the win they so desperately need.
Fit again has scored all six of his goals this season since Matchday 26, chipping in with a further two assists. As Stuttgart need to score to secure their Bundesliga survival, the 24-year-old will need to have his shooting boots on once again.
Andre Breitenreiter, head coach: "We're ready. Apart from when we faced Bayern, we had a chance of beating everyone else we've played at home. My boys always stand up again, even when nobody else believes in them. We have faith in our strengths. The coaching staff and players are a very close-knit bunch."
Huub Stevens, head coach: "We know that if we win we'll stay up, which is why we're only focusing on ourselves. Despite the tense situation, it's also important to be relaxed to a certain extent going into the game. I imagine Paderborn have progressed since we last met them in the first half of the season."
Stuttgart have been playing very well in recent matches, albeit without collecting the desired results. That said, they come into this game on the back of a two-game winning streak, so will be full of confidence. By way of contrast, Paderborn have lost their last two and are the league's worst home side, with just four victories at the Benteler Arena all season.
These two have only ever met once before at this level, drawing 0-0 on Matchday 17 back in December.
Paderborn: Kruse - Heinloth, Strohdiek, Hünemeier, Hartherz - Bakalorz, Vrancic - Koc, Rupp, Stoppelkamp - Lakic
Stuttgart: Ulreich - Schwaab, Rüdiger, Baumgartl, Klein - Gentner, Serey Die - Harnik, Didavi, Kostic - Ginczek