It is a game which needs little introduction, a south versus north battle with potentially serious consequences for the loser as the Bundesliga season heads towards its final weekend.
bundesliga.com has all the important information for this relegation six-pointer...
Only one thing counts for Stuttgart and Hamburg over the course of the next week, and that is survival. Two giants of the German game with illustrious pasts find themselves in a predicament both would have hoped to avoid, but there is nothing left to do but fight for the points they need to pull out of danger.
Huub Stevens will be hoping a key trio from their 2-0 win over Mainz last weekend - Daniel Didavi, Geoffroy Serey Die (r.) and Antonio Rüdiger - will be fit this weekend. All three were training separately during the week due to knocks and it remains to be seen whether they will be fit for Saturday.
Valon Behrami will miss the trip to Stuttgart, with Gojko Kacar (l.) deputising for him once again. There was good news from the treatment room, though, with both Ivo Ilicevic and Cleber returning to team training this week, and both are therefore on the frame to start.
It was not only his goal which made Didavi Stuttgart's hero against Mainz, but the 25-year-old posed a threat that the Swabians have lacked for much of this season. Didavi's strike against the post earlier in the game was further proof that with him in the side, VfB have every chance of getting the goals and points they need to stay up.
Two attributes are essential in a relegation battle: experience and bravery. Fortunately for Bruno Labbadia, he has a man who incorporates both - veteran striker Ivica Olic. The Croatian frontman is the last to admit defeat and his determination and commitment to the cause is HSV's most lethal weapon on Saturday.
Huub Stevens, head coach: "We've now got to take the next step against HSV. All we got last weekend was a win and I've got to ensure the players realise what they still have to do, and that is to prepare for our next game."
Bruno Labbadia, head coach: "With seven points from our last three games, we've put ourselves in a strong position for the final two matches. Now we want to make the most of this in the remaining games. We mustn't - and won't - give up."
After arresting a five-game losing streak, Hamburg have picked up seven points from their last three games under Labbadia to move out of the bottom three. Stuttgart, meanwhile, have picked up only seven points from their last five games, although a 2-0 win over Mainz last weekend was a crucial three points, even if it did not take them off the foot of the table.
These two teams are meeting for the 100th time this weekend, and hardly have any of the 99 previous meetings been so crucial as this one. Stuttgart have won 36 of them with Hamburg slightly ahead with 42, although the Swabians triumphed 1-0 in northern Germany back in December.
Stuttgart: Ulreich - Schwaab, Baumgartl, Rüdiger, Klein - Serey Dié, Gentner - Harnik, Didavi, Kostic - Ginczek
Hamburg Adler - Westermann, Djourou, Rajkovic, Ostrzolek - Van der Vaart, Kacar – Stieber, Jansen, Olic - Lasogga