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The hosts are already guaranteed a place in the UEFA Champions League qualifying round at the very least, but are eager to stay second to secure an automatic place in the group stage. Meanwhile, the guests are just two points off the bottom, so need a win to pull clear of the drop zone.
Full-back Marcel Schäfer (r.) has been ruled out of this game after sustaining a knee injury in Wolfsburg's DFB Cup semi-final on Wednesday. Aaron Hunt (fitness) and Felipe (seizure) will play no part either, but otherwise coach Dieter Hecking has a full squad available to him.
Christian Pander, Leonardo Bittencourt (both thigh) and Artur Sobiech (knee) are all sidelined for this one, but the biggest blow will be the absence of playmaker Lars Stindl (l.), who collected a fifth yellow card of the season last week and is therefore suspended.
Kevin De Bruyne may have shown the strain of a long, draining season in recent games but he nevertheless remains a fearsome opponent. With ten league goals and 17 assists already this term, he is without doubt the hosts' main dangerman.
Hannover have a nimble-footed playmaker of their own in Hiroshi Kiyotake. The Japan international is adept at moving between the lines and has the passing ability to pick apart the meanest of defences. The visitors will need him to be at his very best in the absence of Stindl.
Dieter Hecking, head coach: "We’ve not really had any time to celebrate reaching the DFB Cup final. If the lads win this home game they might get a couple of days off in order to enjoy what they have achieved."
Michael Frontzeck, head coach: "We know what to expect and we've prepared ourselves meticulously for this game. From what I've seen in training over the last few days I'm sure the lads will put up a good fight and hopefully we'll be able to return home with something to show for it."
The Wolves have won two, drawn two and lost one of their last five games, succumbing to a 1-0 defeat away to Gladbach last week. However, they will be buoyed by a over Arminia Bielefeld on Wednesday to reach the DFB Cup final. Hannover are without a win since Matchday 16, drawing six and losing eight in the intervening period.
Wolfsburg have won 13 of the 25 meetings at this level over the years, but that does not mean Hannover are without hope. The Reds have triumphed nine times overall, including in four out of the last five encounters and both of their two most recent trips to the Volkswagen Arena.
Wolfsburg: Benaglio - Vieirinha, Naldo, Klose, Rodriguez - Arnold, Luiz Gustavo - Perisic, De Bruyne, Caligiuri - Dost
Hannover: Zieler - Schmiedebach, Marcelo, Schulz, Albornoz - Sane, Andreasen - Ya Konan, Kiyotake, Prib - Joselu