The 32-year-old has been struck down by a patella injury and will miss the visit to the Allianz Arena, depriving him of an opportunity to put some distance between himself and one of his main rivals for the Torjägerkanone, FC Bayern's Robert Lewandowski.
bundesliga.com previews the action in Bavaria...
Treble-chasing Bayern need just four more wins from their remaining seven games to wrap up a 24th Bundesliga title. Frankfurt, meanwhile, are to all intents and purposes safe from the drop but potentially at risk of their season disappearing into mid-table mediocrity.
On the personnel front, things seem to be going from bad to worse for the Bavarians. This week, Medhi Benatia was ruled out for four weeks, joining Javi Martinez, Franck Ribery, Arjen Robben and David Alaba on the sidelines. Bastian Schweinsteiger is also injured, but Spanish midfielder Thiago Alcantara may be fit enough to start.
Thomas Schaaf's injury worries are comparably serious. Carlos Zambrano and utility man Marco Russ are missing with injury, but surely the bigger blow will be the absence of the league's leading scorer Meier, who has a knee complaint. Haris Seferovic could lead the line in Meier's stead.
In only two substitute appearances, Thiago has already made a huge impact for Bayern after 371 days out injured. Following his cameo in Der Klassiker a week ago, he sunk the winning penalty in the DFB Cup victory over Bayer 04 Leverlkusen in midweek and will likely be the team's most important midfield cog in future weeks.
The absence of top scorer Meier could be the opportunity that Seferovic requires to rediscover his goalscoring form. The Swiss international is a tireless worker but has just one goal in his last ten league appearances. Even so, Schaaf will hope his physical presence can unsettle the home defence.
Pep Guardiola: "We played okay against Leverkusen, but we didn't have the element of surprise. Frankfurt play good football, are an aggressive team and are good to watch, and in [Marc] Stendera, they have a quality player. I hope the fans help us at the Allianz Arena. We need the support."
Kevin Trapp: "We won't be scared going to Munich, we know that Bayern are the team to beat. They have ridiculous quality and even with their injuries, it will be a really difficult game for us. We'll have to give it everything we have to make sure we can put in a decent performance and get a result."
Despite their depleted numbers, Bayern continue their march to glory on three fronts. Last week's win over Borussia Dortmund maintained their ten-point lead in the Bundesliga, and they will host BVB in the last four of the cup after . The Eagles have picked up four points from their last three matches.
Die Münchner boast a markedly superior record in this fixture, having won 46 and drawn 20 of the clubs' 87 top-flight meetings, with a Thomas Müller hat-trick inspiring the Reds to a 4-0 rout in the reverse fixture in November. Eintracht last beat the German record titleholders in the league in March 2010.
Bayern: Neuer - Boateng, Dante, Badstuber - Rafinha, Lahm, Thiago, Bernat - Götze, Müller - Lewandowski
Frankfurt: Trapp - Chandler, Madlung, Anderson, Oczipka - Stendera, Hasebe - Aigner, Kittel, Inui - Seferovic