Joachim Löw's side are already playing catch-up with leaders Poland after four matches and can ill afford any further slip-ups on the bumpy road to France. bundesliga.com previews the action...
Germany are currently joint second in Group D, three points behind Poland and level on seven with the Republic of Ireland and Scotland. With Ireland facing Poland and Scotland up against Gibraltar, the World Cup winners need all three points against second-bottom Georgia to wrestle back control of the group.
Defenders Gia Grigalava and Akaki Khubutia both started last November's 4-0 home defeat to Poland, but neither player has been included in the squad this time around. Empoli FC's Levan Mchedlidze (r.), who's scored just once in Serie A so far this season, is expected to lead the line in a compact 4-5-1 formation.
Holger Badstuber and Karim Bellarabi miss out, but goalkeeper will start after shaking off a knee complaint. Bastian Schweinsteiger, Thomas Müller, Toni Kroos, Mats Hummels and Jerome Boateng were unused substitutes against Australia in midweek and are all set to return to the starting line-up.
Jaba Kankava has been one of his country's standout performers in qualifying and is a regular at Ukrainian Premier League outfit FC Dnipro Dnipropetrovsk. It goes without saying the no-nonsense holding midfielder's remit in Tbilisi will be to get right in the faces of the opposition and cut off Germany's supply line at source.
Just as influential for club as country, returning FC Bayern München forward will be a welcome sight on the team sheet for the travelling fans. The 25-year-old has scored five goals in his last four outings in all competitions and grabbed a brace in the world champions' most recent qualifier against Gibraltar.
Leven Kenia (midfielder, speaking to BILD): "Since the World Cup Germany is on shaky ground, and a result [for Georgia] may be possible."
Löw (head coach): "We'll be playing for the win from the start. We know how important the three points are, the margin of victory is irrelevant. We have to be prepared to do a lot of running, find a way through and be dangerous going forward. I'm confident we can go there and win."
Germany have won just three of their seven post-World Cup outings, with Wednesday's friendly at home to Australia ending in a . Georgia, whose only win in qualifying came against European minnows Gibraltar, warmed up for this one with an unconvincing 2-0 success over Malta.
Georgia have lost all three of their previous games against Germany, who racked up home and away wins when the sides met in Euro 96 qualifying. Löw later oversaw a 2-0 friendly victory over the Crusaders in Rostock back in 2006.
Georgia: Loria - Amisulashvili, Kverkvelia, G. Kashia - Kobakhidze, Navalovsky - Kankava, Makharadze - Okriashvili, Kenia - Mchedlidze
Germany: Neuer - Mustafi, J. Boateng, Hummels - Schweinsteiger - T. Müller, T. Kroos, Özil, Hector - M. Götze, Reus