As ever, bundesliga.com has the pre-match skinny on a game which could see the return of BVB trio Henrikh Mkhitaryan, Ilkay Gündogan and Marco Reus...
With Köln and Dortmund struggling for form, picking up points is an urgent requirement for both clubs. Peter Stöger's side will want to avoid getting dragged into a relegation scrap, while Jürgen Klopp already have a ten-point deficit to make up on league leaders FC Bayern München.
The hosts have pretty much a full squad to choose from, with the exception of Patrick Helmes. Stöger may elect to go with three deep-lying midfielders in an attempt to counter Dortmund's attacking threat, in which case Adam Matuschyk should start. Captain is also expected to return after watching the game in Frankfurt from the bench.
BVB's injury worries eased significantly during the international break, with Messrs Reus, Gündogan and Mkhitaryan all returning to full training. The likelihood is that only one or two of that trio will start, but Pierre-Emerick Aubameyang, who only returned from international duty on Friday, may have to settle for place on the bench.
Something of an unknown just four years ago, has swiftly developed into one of Germany's most promising full-backs. The 24-year-old capped a superb individual display with a goal in the Matchday 7 defeat at Eintracht Frankfurt and is reportedly on the radar of national team head coach Joachim Löw.
The creative spark of the returning could be the key to unlocking a stubborn Köln defence that's conceded just six Bundesliga goals all season. The Armenian has been out of first-team action since injuring his right foot on Matchday 4 and will be champing at the bit to add to his solitary league assist of 2014/15.
Peter Stöger, Köln head coach: "Dortmund have played brilliantly in the Champions League and they are a much better side than their current position suggests."
Jürgen Klopp, Dortmund head coach: "For us it's about getting the points, no matter what happens."
The Billy Goats, whose one and only win of the campaign came away to VfB Stuttgart on Matchday 2, have lost their last three on the bounce. Dortmund have also lost three of their last four league assignments, with the Matchday 7 home defeat to Hamburger SV confirming the club's worst start to a season since 2009/10.
It's been almost 18 months since the two sides last met in what's been a decidedly one-sided fixture down the years. Dortmund racked up 5-0 and 6-1 victories back in 2011/12, extending their winning streak over the men from the Rhine to nine matches in the process.
1. FC Köln: Horn - Brecko, Maroh, Wimmer, Hector - M. Lehmann, Vogt, Matuschyk - Risse, D. Halfar - Ujah
Borussia Dortmund: Weidenfeller - Piszczek, Sokratis, Hummels, Durm - S. Bender, Kehl - H. Mkhitaryan, Kagawa, Großkreutz - Immobile
Find out what happened when Marco Reus, Nuri Sahin, Ilkay Gündogan and Mustafa Amini went head-to-head on FIFA 15, courtesy of the official Bundesliga YouTube channel: