bundesliga.com has the lowdown on the encounter at the Mercedes-Benz Arena...
For Stuttgart the name of the game is moving away from the foot of the table, sitting as they do just a point above bottom side Werder Bremen and with the league's joint-worst goal difference. Leverkusen, conversely, occupy the final Champions League spot and will be keen to cement their place in the top four.
Moritz Leitner returned to Stuttgart from Germany U-21 duty with an ankle complaint and is a doubt, while Filip Kostic may miss out with illness. Antonio Rüdiger (pictured), who in the international break, will revert back to his usual role in central defence.
Simon Rolfes (left) is back in training but the midfielder won't be fit enough for this match. Gonzalo Castro is a doubt with a muscle problem but otherwise Bayer's international players have reported back with no fresh injuries and head coach Roger Schmidt should have almost a full squad to choose from.
Leitner was excellent for Germany's U-21 side in midweek, and looks like he may have turned a corner. He scored his first of the season against Hertha on Matchday 7 - also the first time that he had been involved in two goals in a Bundesliga game - and is one of Armin Veh's first choices in midfield.
Like Rüdiger, Karim Bellarabi also caught the eye playing for Germany during the international break. Starting both matches for die Nationalmannschaft, the forward provided a creative spark for the side and Leverkusen will be hoping the experience means he can add to his three league goals and four assists in 2014/15.
Armin Veh, Stuttgart head coach: Bayer take a lot of risks - I like that - but it's not the tactic that we'll be using.
Roger Schmidt, Leverkusen head coach: Stuttgart are a strong team who have been improving recently. We'll need a good performance.
After a wretched start - just one point from the first five games - Stuttgart's form seems to be picking up with a daw against Borussia Dortmund and a win against Hannover 96, before they suffered a 3-2 reverse at Hertha Berlin. Bayer, meanwhile, are unbeaten in four, although they flattered to deceive in a 2-2 draw with SC Paderborn last time out.
Stuttgart last tasted victory in this fixture in April 2010, a Cacau brace giving them a 2-1 win. The two clubs have met eight times since, with Leverkusen winning six of those encounters. Stefan Kießling, meanwhile, has an almost impossibly good scoring record against VfB: 14 goals in 17 appearances.
Stuttgart: Kirschbaum - Klein, Schwaab, Rüdiger, G. Sakai - Gruezo, Oriol Romeu - Gentner, Leitner, Kostic - Ibisevic
Leverkusen: Leno - Jedvaj, Toprak, Spahic, Wendell - L. Bender, Reinartz - Bellarabi, Calhanoglu, Son - Kießling
Relive Stuttgart’s Daniel Schwaab scoring a comical own goal against his former club last season, courtesy of the official Bundesliga YouTube channel: