bundesliga,com brings you all the pre-match information ahead of a game that will bring Germany's Ruhr region to a standstill, and have fans around the world glued to their screens..
ShinjI Kagawa and Atsuto Uchida have played ten derby matches between them (Uchida in six) and both know full well just what this fixture means to each set of fans. "The rivalry is extreme," said Uchida, with Kagawa adding, "Even when we're away from home, the fans will look to see if Schalke are losing!"
Julian Draxler, Gelsenkirchen-born and bred and a first-hand witness to the importance of this game, is suspended, while Kevin-Prince Boateng (pictured), a BVB player between 2008-09, is a doubt. Captain Benedikt Höwedes is also out with injury, so Roman Neustädter may continue to deputise in defence.
BVB's list of absentees is just as long, it seems. Jakub Blaszczykowski, Henrikh Mkhitaryan, Ilkay Gündogan, Oliver Kirch and Nuri Sahin are all out injured, but Kagawa is fit to play some part. Klopp must decide which of Adrian Ramos and Ciro Immobile, who scored in his last game, will lead the attack.
Klaas-Jan Huntelaar remains Schalke's go-to man in terms of goalscoring, but in the absence of Höwedes, he will also need to be a leader on the pitch for the Royal Blues. The 31-year-old will be hoping to add to his modest record of two goals in eight appearances against the Schwarz-Gelben.
Deprived of Reus and Mkhitaryan, two players who shone in this fixture last season, Ciro Immobile could be set for a starring role this weekend. Having scored his first league goal for his new club on Matchday 5, the wind is most certainly in the Italian's sails.
Jens Keller: "We'll give it everything we have and forget about everything else. It's a really special game for the fans and the entire area."
Jürgen Klopp: "This is one of the standout games in German football. Irrespective of the points, you always have a chance to settle a score in a derby."
Neither side have been in the best form of late but Schalke will at least be confident after winning their first game of the season, 3-0 at SV Werder Bremen during midweek. Dortmund, meanwhile, needed a late Immobile goal to rescue a 2-2 draw against VfB Stuttgart and prevent a third defeat in five matches.
BVB hold a narrow edge in this fixture historically, having won 30 games to Schalke's 29 from their 84 Bundesliga meetings. However, Borussia have also been victorious on three of their last four visits to Schalke, and have more away wins against the Royal Blues - 12 - than against any other current top-flight side.
Schalke: Fährmann - Uchida, Ahyan, Neustädter, Fuchs - Aogo, Boateng - Choupo-Moting, Meyer, Sam - Huntelaar
Dortmund: Weidenfeller - Piszczek, Sokratis, Hummels, Durm - Jojic, Bender - Kagawa, Mkhitaryan, Aubameyang - Immobile
Enjoy more Revierderby highlights below, courtesy of the Bundesliga's official YouTube channel: