bundesliga.com takes a look at all the key news and information ahead of the fixture at the Rheinenergiestadion.
Köln are looking to bounce back from their first defeat of the season and recover the early-season form that saw them keep four straight clean sheets. Conversly, FC Bayern moved to the top of the table with their 4-0 win over SC Paderborn 07, but cannot afford to rest on their laurels: just two points separate them from sixth-placed Borussia Mönchengladbach.
The Billy Goats have no fresh injury concerns ahead of Saturday's clash. After coming off the bench during midweek, Anthony Ujah is pushing for a start up-front, which would mean Yuya Osako dropping into midfield and Slawomir Peszko joining long-term absentees Kazuki Nagasawa and Patrick Helmes on the sidelines.
With the games coming thick and fast for the Reds, head coach Pep Guardiola could well be considering rotating his injury-hit side with an eye on next Tuesday's UEFA Champions League clash with PFC CSKA Moskva. Though there is no change on the injury front, Rafinha and Juan Bernat are expected to feature in the first XI.
Scoring goals is proving an issue for the hosts this season. Yuya Osako is one of only two Köln players to have found the net and they'll need one of their forwards to add to their tally if they are to get anything out of the game. The Japanese international hit six in fifteen games last year - now would be a good time to rediscover that form.
Mario Götze was named Matchday 5's player of the week after bagging a brace against Paderborn and, ominously for Bayern's rivals, the 2014 FIFA World Cup winner is improving with every passing performance. Supported by the creative pairing of Arjen Robben and Thomas Müller, Götze will be key to unlocking the resilient Köln backline.
Köln sporting director Jörg Schmadtke: "We over-complicated things a little [against Hannover]. But we were unlucky to lose and I'm feeling optimistic."
Bayern head coach Pep Guardiola: "We're top, but that isn't important at the moment. We have to improve our style of play so that we can win the important games."
The in the Bundesliga, Köln's unbeaten start to the season - and their run of four consecutive clean sheets - came to an end in the 1-0 loss to Hannover. Up against Bayern's star-studded squad, who sit top having dropped from a possible 15 so far in 2014/15, bouncing back with victory won't be easy.
These sides last met during 2011/12 season in which Köln got relegated, with Bayern recording a comfortable 3-0 and 4-1 double. The hosts can take heart from the fact that, prior to that year, they enjoyed a five-match unbeaten streak against the record titleholders, including a stunning comeback which secured a 3-2 win on home soil in February 2011.
Köln: Horn - Brecko, Maroh, Wimmer, Hector - Vogt, M. Lehmann - Risse, Osako, D. Halfar - Ujah
Bayern: Neuer - Rafinha, J. Boateng, Dante, Juan Bernat - Lahm, Xabi Alonso - Robben, T. Müller, M. Götze - Lewandowski