bundesliga.com rounds up everything you need to know ahead of the clash between the southwestern rivals...
After seeing off SC Freiburg on the opening day of the season, Frankfurt are still looking for their second win in the current campaign, while Mainz could move top of the table if they manage to get a better result than leaders SC Paderborn - who are playing away to FC Bayern München - on Tuesday.
The Eagles will have to do without left-back (pictured) for several months due to a cruciate ligament tear suffered against Schalke. Slobodan Medojevic is another first-choice unavailable on Tuesday after seeing red last weekend, with Stefan Aigner likely to replace the midfielder.
Newly-signed Spanish winger Jairo (pictured, l.) may well be handed a starting role following an impressive performance from the bench in the recent 2-0 win against Borussia Dortmund, while experienced central defenders Philipp Wollscheid and Nicolce Noveski are both sidelined with injuries.
Having only been used intermittently last season, Japanese attacking midfielder has started every game so far this term, showing the great form that saw him score six and lay on another eight goals in the 2012/2013 campaign.
Currently on four goals and topping the current goalscorers' charts, Shinji Okazaki is in the form of his life. The 28-year-old, already the most prolific Japanese player ever to grace the Bundesliga, was also on target in the latest win against Dortmund.
Eintracht coach Thomas Schaaf (pictured): "It will be an exciting and difficult challenge. Mainz have proved themselves capable of very strong performances."
Mainz coach Kasper Hjulmand: "Okazaki is playing very well but we can still improve our whole attacking play. Hopefully we can show that against Frankfurt."
Eintracht seem to have carried last term's indifferent form into the current campaign, having registered a win and two draws - including last weekend's 2-2 at Schalke - and suffered one defeat so far. Mainz, meanwhile, have flown out of the traps, with the recent 2-0 victory over title hopefuls Borussia Dortmund the pick of a run that has left them in an impressive second place.
Local bragging rights are at stake when Mainz travel to Frankfurt, with less than 50 kilometres separating the two cities. Having only won one and lost three of the last five meetings against their local rivals, Eintracht Frankfurt will be keen to improve on that record.
Eintracht: Trapp - Ignjovski, Zambrano, Anderson, Oczipka - Hasebe, Russ - Aigner, Meier, Inui - Seferovic
Mainz: Brosinski, Bell, Jara, Junior Diaz - Geis, Baumgartlinger - Jairo, Malli, Hofmann - Okazaki