In its first installment for over two years, the match-up of two of German football's powerhouses looks set to be a rip-roaring affair, if the sides' successful starts to the season are anything to go by.
Primarily, in what is always a hotly-contested derby, both teams' aim will be to avoid defeat. Indeed, Köln and Gladbach's starts to the season have mirrored each other: they come into this game on five points with two draws and one win under their belts. Although the Foals have found the net more, Köln are yet to concede a goal.
Köln coach Peter Stöger is likely to opt for the same unbreachable back four, meaning exciting defensive prospect Tomas Kalas, on loan from Chelsea FC, will have to wait for his first Bundesliga start. Nigerian international Anthony Ujah (pictured) will lead the line with Japanese star Yuya Osako in support.
Gladbach's UEFA Europa League involvement means Andre Hahn, Ibrahima Traore and the in-form Raffael should return after starting the 1-1 draw with Villarreal CF on the bench. USA full-back Fabian Johnson (pictured) is likely to see regular action over the coming months, however, after Tony Jantschke's ankle injury.
After an inauspicious Bundesliga debut against Hamburger SV, Yuya Osako bounced back with his first goal for his new club within 25 minutes of Matchday 2's clash with VfB Stuttgart. The Japan international striker has grown into his more withdrawn role, and possesses the subtle movement to trouble the Gladbach defence.
After a brilliant assist and his first goal of the season in Matchday 3's 4-1 hammering of FC Schalke 04, Gladbach's Raffael is the Bundesliga man in form. The Brazilian's creativity, speed and eye for a pass will be worrying the hitherto-unbreachable Köln defence.
Andre Hahn (pictured): "This match means everything for Gladbach fans. It's a special Bundesliga game and we want to take all three points."
Peter Stöger: "It's going to be a special game, but also a tough game. Everyone's enjoying training and we can hardly wait."
After promotion as Bundesliga 2 champions last season, Köln have blown away any doubts about their ability to compete at this level with a brilliant start which has seen Timo Horn (pictured) record three clean sheets. After two draws in their first two games, Gladbach's 4-1 win over Schalke last week showed them to be hitting their straps.
Despite being a mere 62 kilometres apart, fans of two of Germany's biggest clubs have had to wait since April 2012 to face off at this level after Köln's relegation. In that doomed season, they lost 3-0 home and away to their great rivals, results which extended Gladbach's unbeaten run over the Billy-Goats to seven games.
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Watch Marco Reus taking on Lukas Podolski in the last Rhine derby in April 2012 courtesy of the official Bundesliga YouTube channel: