bundesliga.com lines up the pertinent pre-match facts ahead of the penultimate fixture of the weekend...
It's still very early days, but unbeaten Bundesliga leaders Bayer 04 look a good bet to at least match last season's fourth-placed finish. The same cannot be said of Wolfsburg, who have collected just two points after pushing Leverkusen all the way in the race for UEFA Champions League football in 2013/14.
Dieter Hecking may make changes to the side that lost 4-1 at Everton FC in the UEFA Europa League on Thursday night, with Aaron Hunt and Nicklas Bendtner chief candidates for a starting berth. Joshua Guilavogui serves a mandatory one-match ban following his sending off for two bookable offences on Matchday 3.
has been ruled out through injury, so Tin Jedvaj is expected to move into the centre of defence with either Giulio Donati or Stefan Reinartz filling in at right-back. Australian international Robbie Kruse could make the bench following almost eight months out with knee ligament damage.
Not for the first time, came to the Wolves' rescue at Hoffenheim last weekend with his second league goal of the season. Despite being 35, the veteran Croatian striker can still be relied on to go the distance and, more importantly, to get himself in the right position almost invariably at the right time.
A creative impetus and goalscorer to boot, continues to improve by the week at his new club. The archetypal Zehner bagged his first goal in Werkself colours in last Friday's 3-3 draw with SV Werder Bremen and travels to Wolfsburg with two assists in three league outings to his name.
Maximilian Arnold: "We didn't see [the Everton game] going that way, but we can't afford to bury our heads in the sand. We have to keep working."
Roger Schmidt: "[Wolfsburg] should not be judged on recent results. It'll be a big ask for us to get a result."
After dropping points against Bremen, Roger Schmidt's men came unstuck in the group stages of the Champions League at AS Monaco FC. Wolfsburg were also beaten in midweek, with a penalty shoot-out victory over SV Darmstadt 98 in the first round of the DFB Cup their only success in all competitions so far this season.
The two sides exchanged 3-1 home wins last season, but the head-to-head record books favour Leverkusen overall, with the Rhineland club unbeaten in their last ten league games against Wolfsburg at the BayArena.
Wolfsburg: Benaglio - Jung, Naldo, Knoche, Rodriguez - Malanda, Luiz Gustavo - Caligiuri, Arnold, De Bruyne - Olic
Leverkusen: Leno - Donati, Jedvaj, Spahic, Boenisch - Castro, Bender - Bellarabi, Son - Calhanoglu - Kießling