The Mexico international, who has represented his country on 99 occasions, could make his Werkself debut against VfB Stuttgart on Saturday.
"Great European league"
"The Bundesliga has a fantastic reputation in Spain," said the 27-year-old. "It's something special for me now to be able to play in this great European league having played in the Primera Division. Bayer have been a top side in German football for many years and they have also been a force in the Champions League."
"I'm therefore pleased that the transfer has worked out. This offer from Leverkusen was a great chance for me to start something new." The pint-sized wide player, comfortable in both a defensive and an attacking role on the left, was one of Leverkusen's leading targets this winter. "Andre Guardado is a very experienced player," said Leverkusen's sporting director Rudi Völler. "Given his versatility, Andres fits the bill precisely for what we were after. We are convinced he will give our team a further boost."