The 41-year-old Swiss, whose last post was at Super League side FC Aarau, has signed a long-term contract with der Club and will take charge of training for the first time on Wednesday.
"Rene has accomplished a great deal in challenging circumstances in his previous posts," explained sporting and public relations director Martin Bader. "He has a reputation in Switzerland of doing a good job in developing young talent and has proved that he can build a team. From our analysis, we concluded that this combination made him the right candidate for our current situation."
Weiler himself was delighted with the opportunity of beginning his coaching career in Germany with Nürnberg. "It's an honour and something that fills me with pride to have been entrusted with this job," he admitted. "I'm looking forward to the challenge of taking charge of a club with such tradition and great fan culture."
Nürnberg, relegated from the Bundesliga in 2013/14, are currently down in 14th place in the second tier and have lost seven of 13 league matches, the last of those coming at SV Sandhausen on Matchday 13.