Cologne - Bayer 04 Leverkusen travel to Barcelona for their second UEFA Champions League group game on Tuesday evening, and Roger Schmidt's side have cause for optimism ahead of their clash with the reigning European champions (kick-off 20:45 CEST / 18:45 GMT).

Leverkusen got their Group E campaign off to a flying start two weeks ago with a 4-1 victory over BATE Borisov. Furthermore, Barcelona will be without talismanic forward Lionel Messi, who is absent with a knee injury.

Top facts

  • The last time Leverkusen played in Barcelona's Camp Nou, in 2012, they were thrashed 7-1. A certain Lionel Messi scored five goals on that evening.
  • Bayer have played 15 games on Spanish soil and lost 10 of them.
  • Leverkusen and Barcelona also met in the group stages back in 2001. That year, Luis Enrique scored for Barcelona in both the home and away fixtures. Enrique is now Barcelona coach.
  • Barcelona goalkeeper Marc-André ter Stegen doesn't have the best record against Leverkusen. Of his six games against them while he was playing for Borussia Mönchengladbach, ter Stegen won only one and suffered two defeats.
  • Leverkusen's only piece of European silverware came in the 1988 UEFA Cup, where they beat Barcelona in the quarter-finals and city rivals RCD Espanyol in the final.

Possible line-ups:

Barcelona: ter Stegen - Sergi Roberto, Piqué, Mascherano, Jordi Alba - Rakitic, Busquets, Iniesta - Suarez, Sandro Ramirez, Neymar

Leverkusen: Leno - Donati, Tah, Papadopoulos, Wendell - Kramer, L. Bender - Bellarabi, Calhanoglu - Kießling, Hernandez