Dortmund lost all three of their away fixtures in last season's competition, including a 2-1 defeat to English club Arsenal, but travel to the Etihad Stadium with a renewed sense of confidence after Sunday's rampant 5-0 win over Borussia Mönchengladbach.
Group of death
After making a stuttering start to the new campaign, the Yellow-Blacks hit their stride last time out, putting on the kind of show the Signal Iduna faithful had become accustomed to en route to seeing their side lift back-to-back Bundesliga titles.
However, the Champions League presents an altogether different proposition, with Dortmund unable to make it beyond the group stages of the competition in their previous two attempts. Points on the board following their opening Group D clash against Ajax stand them in good stead this season, as the domestic double winners look for a way out of the fabled 'group of death'.
In Manchester City, Dortmund face a team unbeaten in Europe at the Etihad Stadium in their last 17 outings. FC Midtjylland were the last side to win on City territory in the second qualifying round of the then UEFA Cup, but the Citizens haven't had it all their own way since lifting their maiden Premier League crown in May 2012.
Roberto Mancini's charges have failed to win their last two home outings and greet Dortmund desperately seeking a first Champions League win of the season after throwing away a 2-1 lead against Real Madrid last time out, ultimately losing 3-2. "The situation is now such that it's vital for them to win this game," said Dortmund's 1997 Champions League winner Steffen Freund.
Lewandowski to start
Klopp is able to pick from a full-strength squad of players after coming through the game against Mönchengladbach unscathed. Polish striker Robert Lewandowski was rested at the weekend and will almost certainly come in at the expense of Julian Schieber.
Maicon, Jack Rodwell and Micah Richards remain sidelined for the hosts, with Mancini expected to name a similar starting eleven to that which beat Fulham in the Premier League last weekend. Former VfL Wolfsburg striker Edin Dzeko scored the winner on that occasion, but is unlikely to usurp Carlos Tevez in the lone striker role.
Borussia Dortmund: Weidenfeller - Piszczek, Subotic, Hummels, Schmelzer - Kehl, Gundogan, Blaszczykowski, Gotze, Reus - Lewandowski
Manchester City: Hart, Zabaleta, Kompany, Nastasic, Clichy - Garcia, Barry, Silva, Yaya Toure, Aguero - Tevez