- Günter returns from suspension.
- Philipp and Söyüncü ruled out.
- Papadopoulos out for three weeks.
Official Fantasy Bundesliga Managers take note: bundesliga.com is on hand to provide likely line-ups as well as injury and suspension news ahead of Matchday 12.
SC Freiburg head coach Christian Streich said his side "need to be better than good", but will be forced to make at least two changes to his starting line-up with centre-back Caglar Söyüncü and top scorer Maximilian Philipp both unavailable for selection. Manuel Gulde and Olympic silver medalist Nils Petersen are expected to feature in their stead, while Christian Günter, back from suspension, should slot in at left-back.
Watch: Highlights of Freiburg's six-goal thriller against Mainz on Matchday 11:
For Leipzig, Greek centre-back Kyriakos Papadopoulos will be unable to replace Marvin Compper - who was forced off injured in the win over Bayer 04 Leverkusen - after having to undergo a knee operation that will keep him out for three weeks. Lukas Klostermann, Bernardo and Ken Gipson are all "making good progress", but will not feature on Friday night.
Watch: Highlights of Leipzig's win in Leverkusen that took them to the Bundesliga summit:
Freiburg possible line-up: Schwolow - Stenzel, Torrejon, Gulde, Günter - Höfler, Abrashi - Frantz, Grifo - Niederlechner, Petersen
Absentees: Günter (suspended), Kempf (fitness), Guede (knee), Nielsen (fitness), Söyüncü (concussion), Philipp (torn ankle ligaments), Meffert (thigh)
Coach: Christian Streich
Leipzig possible line-up: Gulacsi - Schmitz, Ilsanker, Orban, Halstenberg - Demme, Keita - Sabitzer, Forsberg - Werner, Poulsen
Absentees: Klostermann (knee), Bernardo (knee), Compper (ankle)
Coach: Ralph Hasenhüttl
SC Freiburg host RB Leipzig at the Schwarzwald-Stadion, with the game kicking off at 20:30CET/19:30GMT on 25 November.