Coincidentally, the former SV Werder Bremen icon took his coaching bow in a 1-0 win over the Royal Blues back on 11 May 1999, with Otto Rehhagel (832), Jupp Heynckes (642), Erich Ribbeck (569) and the late Udo Lattek (522) the select few celebrated top-flight tacticians to have made it to club 500 down the years.
Frankfurt are still scoring goals, but with no win in their last eight games the Eagles have fallen seven points adrift of the top six since the winter break. Schalke, on the other hand, start the weekend third in both the league and form table, albeit with three other sides hot on their heels in the race for UEFA Champions League football.
With serving a mandatory one-match ban after picking up his fifth yellow card of the season on Matchday 20 and Bamba Anderon ruled out, Alexander Madlung is set to partner Marco Russ at the heart of the back four. The game comes too soon for recovering duo Constant Djakpa and Nelson Valdez, however.
19-year-old will continue in goal in the absence of Ralf Fährmann and Fabian Giefer. Sidney Sam missed out last weekend, but returned to training on Thursday and should at least make the bench. Klaas-Jan Huntelaar still has two games to serve of a four-match ban following his sending off against Hannover 96.
's first league goal of the year earned Frankfurt a deserved share of the spoils at Augsburg last weekend. The Bundesliga's top scorer has made a career out of being in the right place at the right time and proved once again at the SGL Arena that he's just as clinical - if not more so - than he ever was.
will have to put all his experience to good use against the free-scoring Meier. The World Cup-winning defender is thriving alongside Joel Matip and Matija Nastasic, Roberto Di Matteo's watertight back line having conceded just one league goal in three games since the turn of the year.
Thomas Schaaf (Frankfurt head coach): "Getting three points against Schalke on Saturday is much more important than me celebrating my 500th match as a head coach."
(Schalke captain): "We'll look to keep things tight and limit the space for Frankfurt's forwards. We're going there to win."
Frankfurt hit back from two goals down to rescue a point at Augsburg, but remain winless since Matchday 14. Visitors Schalke are unbeaten in their last five, amassing seven points from a possible nine so far in 2015.
Messrs Draxler, Boateng and Medojevic saw red as nine-man Schalke held the ten-man Eagles to a turbulent 2-2 draw at the Veltins Arena on Matchday 4. Last season's clash in Frankfurt was no less exciting, with Höwedes' late equaliser denying the hosts their second successive home win over the Royal Blues in a barnstorming 3-3 draw.
Frankfurt: Trapp - Chandler, Russ, Madlung, Oczipka - Stendera, Hasebe - Aigner, Inui - Meier, Seferovic
Schalke: Wellenreuther - Höwedes, Matip, Nastasic - Uchida, Fuchs - Neustädter - Höger, M. Meyer - K.-P. Boateng, Choupo-Moting