And with this fixture averaging almost three goals per game over the years entertainment is guaranteed, so allow bundesliga.com to fill you in on what else to expect...
For the hosts, currently third from bottom, this game is all about finally getting a foothold in the 2014/15 season to build momentum prior to the winter break. Fifth-placed Leverkusen on the other hand are eyeing the points themselves with a view to keeping pace at the top of the standings following last week's hard-fought win over Schalke.
The hosts will be without injured trio Rene Adler (knee), Per Jiracek (knee), Slobodan Rajkovic (fitness) and Maximilian Beister (fitness) on Saturday. Now that (r.) is back in attacking midfield having overcome injury, Lewis Holtby could potentially make way for the Dutchman.
Leverkusen's Gonzalo Castro (torn muscle), Stefan Reinartz (eye) and Simon Rolfes (ankle) are all unavailable for the trip north. A defensive reshuffle is in order too, as teenager Tin Jedvaj is suspended after being sent off in the 85th minute against Schalke on Matchday 9, while former Hamburg midfielder is a doubt due to a foot injury. Attacker (l.), another ex-HSV star, is likely to start for Leverkusen.
HSV have scored a pitiful three league goals so far this term, a shortcoming they should get chances to rectify against an attacking Leverkusen side that tend to leave gaps at the back. With that in mind, striker , who found the net in the 3-1 DFB Cup defeat against FC Bayern München on Wednesday, will have a crucial part to play.
Much will depend on how former Hamburg playmaker handles the intense focus that will be placed on him upon his return to the Imtech Arena should he be available. Lethal from set-pieces, as Schalke discovered last week, the 20-year-old also knits Bayer's attacks together from in attacking midfield and has proven himself to be a man for the big occasion several times already.
(r.): We want to finally get a home win against Leverkusen, and pick up some points for the fans.
Roger Schmidt, Leverkusen coach: Hamburg have a good team with lots of potential. On paper they’re much better than their present place in the table indicates.
HSV never looked like beating Bayern in the DFB Cup second round on Wednesday and have only earned one point from their last two league games, losing 3-0 to Hertha Berlin on Matchday 9. Leverkusen beat Schalke last week but struggled to get the better of regional league side 1. FC Magdeburg in the Cup and only went through 7-6 after a penalty shootout.
The overall balance of power is marginally in HSV's favour, having won 26 and lost 25 of the 70 league matches contested with Leverkusen. However, the Werkself have had the upper hand lately, winning five and drawing four of the the ten most recent matches. Hamburg triumphed 2-1 when the sides last met in April this year.
Hamburg: Drobny - Diekmeier, Djourou, Westermann, Ostrzolek - Behrami, Arslan - Müller, van der Vaart, Jansen - Lasogga
Leverkusen: Leno - Donati, Toprak, Spahic, Wendell - Bender, Papadopoulos - Bellarabi, Calhanoglu, Son - Kießling