With fresh faces chomping at the bit to impress Joachim Löw and fans flocking to see their heroes in a stadium proudly emblazoned with die Nationalmannschaft's four stars, bundesliga.com previews what is set to be a thrilling encounter between two of football's most storied international ensembles.
The World Cup winners are using Wednesday's friendly to warm up for their first UEFA European Championship 2016 qualifier against Scotland, while the Argentinians have one eye on the CONMEBOL Copa America in Chile next summer, and travel to Germany under the stewardship of former FC Barcelona boss Gerardo Martino.
There has been change aplenty for Joachim Löw's Germany since their fourth World Cup win. Philipp Lahm, Per Martesacker and Miroslav Klose have retired, while Bastian Schweinsteiger, ruled out for this one, has been named . Marco Reus (pictured) is back in the squad, though, and could line up alongside Borussia Dortmund team-mate Erik Durm in Löw's starting XI.
Argentina's captain and star man, Lionel Messi (pictured), is suffering from a groin injury and won't feature. His partner-in-crime up front, Ezequiel Lavezzi is also a doubt, while World Cup stars Maxi Rodriguez, Ezequiel Garay and Rodrigo Palacio haven't even made the journey. Martino has, therefore, recalled wingers Erik Lamela and Nicolas Gaitan.
After missing the World Cup with an ankle injury, Marco Reus (pictured) will be desperate to reintegrate himself into the Germany fold and add to his 21 international appearances and seven goals. Indeed, in the likely absence of Mesut Özil, the Dortmund attacker should start in a front four with Mario Götze, Thomas Müller and Andre Schürrle.
Sergio Agüero will be the man tasked with filling the talismanic Messi's goalscoring boots. The Manchester City FC striker has two goals in three games at the start of the Premier League season, and after a disappointing World Cup by his own high standards, will want to send a timely reminder of his qualities to coach Martino. He has the pace, power and finishing ability to trouble what might be a youthful Germany defence.
Löw: "We will be facing sides even more motivated against us now. We've got some new players who we will try to integrate and the aim has always got to be to get better and better. We know where we can still improve.''
Martino: "The most important thing for us in this friendly is building a good atmosphere in the group."
Germany's triumph in Rio de Janeiro was the culmination of an unbeaten run which now stretches back to June 2013. Die Nationalmannschaft enjoyed a near-flawless qualification campaign for the World Cup, and are aiming to repeat the feat in European Championship qualifying. Argentina's 1-0 loss to Germany in Rio was their first since a 3-2 reverse in Uruguay in October 2013, and they only lost twice in 16 World Cup qualification encounters.
This fixture is the most played World Cup final ever (1986, 1990, 2014), and its history drips with tales and legends. The sides' recent records, beyond the 2014 World Cup final, are fairly balanced. Germany have prevailed twice since 2006, and Argentina also on two occasions.
Germany: Neuer - Großkreutz, Rüdiger, Höwedes, Durm - Kramer, Kroos - Reus, Götze, Schürrle - Müller
Argentina: Romero - Zabaleta, Fernandez, Demichelis, Rojo - Mascherano, Biglia - Di Maria, Gaitan - Agüero, Higuain